Reference Report

Reference
Citation	Colombani, J., Bianchini, L., Layalle, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carre, C., Noselli, S., Leopold, P. (2005). Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310(5748): 667--670. (Export to RIS)
FlyBase ID	FBrf0190605
Publication Type	Research paper
PubMed ID	16179433
PubMed Abstract	All animals coordinate growth and maturation to reach their final size and shape. In insects, insulin family molecules control growth and metabolism, whereas pulses of the steroid 20-hydroxyecdysone (20E) initiate major developmental transitions. We show that 20E signaling also negatively controls animal growth rates by impeding general insulin signaling involving localization of the transcription factor dFOXO and transcription of the translation inhibitor 4E-BP. We also demonstrate that the larval fat body, equivalent to the vertebrate liver, is a key relay element for ecdysone-dependent growth inhibition. Hence, ecdysone counteracts the growth-promoting action of insulins, thus forming a humoral regulatory loop that determines organismal size.
DOI
Related Publication(s)
Supplementary material	Antagonistic actions of ecdysone and insulins determine final size in Drosophila. [FBrf0191480]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (10)
	EcR^{B1-ΔC655.F645A.Scer\UAS} EcR^{dsRNA.Scer\UAS.cCa} foxo²¹ Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pi3K92E^{Scer\UAS.T:Hsap\MYC} Scer\GAL4^arm.PS Scer\GAL4^P0206 Scer\GAL4^ppl.PP step^{αTub84B.T:Avic\GFP-EGFP} T:Avic\GFP^EGFP
Constructs (7)
	P{Dp110^D954A} P{GAL4-arm.S} P{ppl-GAL4.P} P{tGPH} P{UAS-EcR.B1-ΔC655.F645A} P{UAS-EcR-RNAi} P{WT-Dp110}
Genes (9)
	dib EcR foxo phm Pi3K92E Scer\GAL4 step T:Hsap\MYC Thor
Insertions (1)
	P{GAL4}P0206