Reference Report

Reference
Citation	Ha, E.M., Oh, C.T., Bae, Y.S., Lee, W.J. (2005). A direct role for dual oxidase in Drosophila gut immunity. Science 310(5749): 847--850. (Export to RIS)
FlyBase ID	FBrf0190609
Publication Type	Research paper
PubMed ID	16272120
PubMed Abstract	Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities. Adult flies in which dDuox expression is silenced showed a marked increase in mortality rate even after a minor infection through ingestion of microbe-contaminated food. This could be restored by the specific reintroduction of dDuox, demonstrating that this oxidase generates a unique epithelial oxidative burst that limits microbial proliferation in the gut. Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia.
DOI
Related Publication(s)
Supplementary material	A direct role for dual oxidase in Drosophila gut immunity. [FBrf0191535]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (11)
	Duox^{dsRNA.Scer\UAS} Duox^{PHD.MtnA.T:SV5\V5} Duox^Scer\UAS.cHa Duox^{ΔPHD.Scer\UAS} Hsap\DUOX1^Scer\UAS.cHa Hsap\DUOX2^Scer\UAS.cHa Irc^{dsRNA.Scer\UAS} Nox^{dsRNA.Scer\UAS} Scer\GAL4^c564 Scer\GAL4^cad-em459 Scer\GAL4^da.G32
Constructs (4)
	P{GAL4-da.G32} P{UAS-Duox.RNAi} P{UAS-Irc.RNAi} P{UAS-Nox.RNAi}
Genes (7)
	Duox Hsap\DUOX1 Hsap\DUOX2 Irc Nox Scer\GAL4 T:SV5\V5
Insertions (2)
	P{GawB}c564 P{GawB}cad^em459