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Citation
Kittel, R.J., Wichmann, C., Rasse, T.M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D.A., Pawlu, C., Kellner, R.R., Willig, K.I., Hell, S.W., Buchner, E., Heckmann, M., Sigrist, S.J. (2006). Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release.  Science 312(5776): 1051--1054.
FlyBase ID
FBrf0190611
Publication Type
Research paper
Abstract
The molecular organization of presynaptic active zones during calcium influx-triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED (stimulated emission depletion) fluorescence microscopy. At brp mutant active zones, electron-dense projections (T-bars) were entirely lost, Ca2+ channels were reduced in density, evoked vesicle release was depressed, and short-term plasticity was altered. BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
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Related Publication(s)
Note
Neuroscience. Gatekeeper at the synapse.
Atwood, 2006, Science 312(5776): 1008--1009 [FBrf0192791]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Aberrations (1)
    Alleles (6)
    Genes (5)
    Insertions (2)
    Transgenic Constructs (3)