Reference Report

Reference
Citation	Anderson, J., Bhandari, R., Kumar, J.P. (2005). A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye. Genetics 171(4): 1655--1672. (Export to RIS)
FlyBase ID	FBrf0190701
Publication Type	Research paper
External Crossreferences
PubMed ID	15998717
PubMed Abstract	Drosophila CREB-binding protein (dCBP) is a very large multidomain protein, which belongs to the CBP/p300 family of proteins that were first identified by their ability to bind the CREB transcription factor and the adenoviral protein E1. Since then CBP has been shown to bind to >100 additional proteins and functions in a multitude of different developmental contexts. Among other activities, CBP is known to influence development by remodeling chromatin, by serving as a transcriptional coactivator, and by interacting with terminal members of several signaling transduction cascades. Reductions in CBP activity are the underlying cause of Rubinstein-Taybi syndrome, which is, in part, characterized by several eye defects, including strabismus, cataracts, juvenile glaucoma, and coloboma of the eyelid, iris, and lens. Development of the Drosophila melanogaster compound eye is also inhibited in flies that are mutant for CBP. However, the vast array of putative protein interactions and the wide-ranging roles played by CBP within a single tissue such as the retina can often complicate the analysis of CBP loss-of-function mutants. Through a series of genetic screens we have identified several genes that could either serve as downstream transcriptional targets or encode for potential CBP-binding partners and whose association with eye development has hitherto been unknown. The identification of these new components may provide new insight into the roles that CBP plays in retinal development. Of particular interest is the identification that the CREB transcription factor appears to function with CBP at multiple stages of retinal development.
BIOSIS ID	2006.188256
Zoological Record ID
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Language of Publication	English
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ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(2L)dac-4 Df(3L)H99
Alleles (40)
	ade2^unspecified CG1707^unspecified cgd^unspecified CrebA^Scer\UAS.cRa CrebA^unspecified CrebB-17A^unspecified dpp^unspecified Egfr^unspecified enc^unspecified ey^unspecified eya^D1 gl^unspecified kni^unspecified Kr^unspecified l(3)71DEc^E86 l(3)72Df³ l(3)L3659^L3659 lilli^unspecified ll^unspecified luc^unspecified nej^{Scer\UAS.T:SV5\V5} nej^{ΔBHQ.Scer\UAS} nej^{ΔNZK.Scer\UAS} nej^ΔQ.Scer\UAS rho^unspecified RhoGAP93B^unspecified rn^unspecified Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scr^unspecified so³ sog^unspecified spi^unspecified srp^unspecified sty^unspecified Tpl^unspecified Tsp42Ea^unspecified Ubx^unspecified Xrp1^unspecified
Constructs (8)
	P{GAL4-ey.H} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{UAS-CrebA.R} P{UAS-nej.wt-V5} P{UAS-nej.ΔBHQ} P{UAS-nej.ΔNZK} P{UAS-nej.ΔQ}
Genes (40)
	ade2 ato CG1707 cgd CrebA CrebB-17A dac dpp Egfr elav enc ey eya gl Iap2 kni Kr l(3)71DEc l(3)72Df l(3)L3659 lilli ll luc nej rho RhoGAP93B rn Scer\GAL4 Scr so sog spi srp sty T:SV5\V5 th Tpl Tsp42Ea Ubx Xrp1