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Citation
Mahoney, M.B., Parks, A.L., Ruddy, D.A., Tiong, S.Y.K., Esengil, H., Phan, A.C., Philandrinos, P., Winter, C.G., Chatterjee, R., Huppert, K., Fisher, W.W., L'Archeveque, L., Mapa, F.A., Woo, W., Ellis, M.C., Curtis, D. (2006). Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers.  Genetics 172(4): 2309--2324.
FlyBase ID
FBrf0190744
Publication Type
Research paper
Abstract
Presenilin is the enzymatic component of gamma-secretase, a multisubunit intramembrane protease that processes several transmembrane receptors, such as the amyloid precursor protein (APP). Mutations in human Presenilins lead to altered APP cleavage and early-onset Alzheimer's disease. Presenilins also play an essential role in Notch receptor cleavage and signaling. The Notch pathway is a highly conserved signaling pathway that functions during the development of multicellular organisms, including vertebrates, Drosophila, and C. elegans. Recent studies have shown that Notch signaling is sensitive to perturbations in subcellular trafficking, although the specific mechanisms are largely unknown. To identify genes that regulate Notch pathway function, we have performed two genetic screens in Drosophila for modifiers of Presenilin-dependent Notch phenotypes. We describe here the cloning and identification of 19 modifiers, including nicastrin and several genes with previously undescribed involvement in Notch biology. The predicted functions of these newly identified genes are consistent with extracellular matrix and vesicular trafficking mechanisms in Presenilin and Notch pathway regulation and suggest a novel role for gamma-tubulin in the pathway.
PubMed ID
PubMed Central ID
PMC1456381 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference