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Reference
Citation
Müller, D., Kugler, S.J., Preiss, A., Maier, D., Nagel, A.C. (2005). Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster.  Genetics 171(3): 1137--1152.
FlyBase ID
FBrf0190751
Publication Type
Research paper
Abstract
Overexpression of Hairless (H) causes a remarkable degree of tissue loss and apoptosis during imaginal development. H functions as antagonist in the Notch-signaling pathway in Drosophila, and the link to growth and apoptosis is poorly understood. To further our insight into H-mediated apoptosis, we performed two large-scale screens for modifiers of a small rough eye phenotype caused by H overexpression. Both loss- and gain-of-function screens revealed known and new genetic interactors representing diverse cellular functions. Many of them did not cause eye phenotypes on their own, emphasizing a specific genetic interaction with H. As expected, we also identified components of different signaling pathways supposed to be involved in the regulation of cell growth and cell death. Accordingly, some of them also acted as modifiers of proapoptotic genes, suggesting a more general involvement in the regulation of apoptosis. Overall, these screens highlight the importance of H and the Notch pathway in mediating cell death in response to developmental and environmental cues and emphasize their role in maintaining developmental cellular homeostasis.
PubMed ID
PubMed Central ID
PMC1456817 (PMC) (EuropePMC)
Associated Information
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Other Information
Secondary IDs
  • FBrf0191541
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Genetics
Title
Genetics
Publication Year
1916-
ISBN/ISSN
0016-6731
Data From Reference
Aberrations (62)
Alleles (98)
Genes (101)
Natural transposons (1)
Insertions (10)
Experimental Tools (1)
Transgenic Constructs (13)