Reference Report

Reference
Citation	Cafferty, P., Yu, L., Long, H., Rao, Y. (2006). Semaphorin-1a functions as a guidance receptor in the Drosophila visual system. J. Neurosci. 26(15): 3999--4003. (Export to RIS)
FlyBase ID	FBrf0191042
Publication Type	Research paper
PubMed ID	16611816
PubMed Abstract	The evolutionarily conserved Semaphorin family proteins are well known axon guidance ligands that mediate both attractive and repulsive responses in invertebrates and vertebrates. In this study, we show that the Drosophila Semaphorin-1a (Sema1a), a transmembrane Semaphorin, is required cell autonomously in adult photoreceptor (R-cell) axons for the establishment of an appropriate topographic termination pattern in the optic lobe. Loss of sema1a disrupts the association of neighboring R-cell growth cones leading to defects in local termination pattern, whereas overexpression of sema1a induces the hyper-fasciculation of R-cell axons. The function of Sema1a in R-cell axon guidance absolutely requires its cytoplasmic domain. We propose that Sema1a functions as a receptor in regulating R-cell axon guidance in the Drosophila visual system.
DOI	10.1523/JNEUROSCI.3845-05.2006
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Aberrations (2)
	Df(2L)N22-5 Df(3R)swp2^MICAL
Alleles (9)
	Ecol\lacZ^{ro.T:Btau\MAPT} Fas2^Scer\UAS.cLa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} nvy^Scer\UAS.cTa Scer\GAL4^elav-C155 Scer\GAL4^GMR.PF Sema-1a^k13702 Sema-1a^Scer\UAS.cYa Sema-1a^{Δcyto.Scer\UAS.T:Hsap\MYC}
Constructs (7)
	P{GAL4-ninaE.GMR} P{ro.lacZ-tau.G} P{UAS-Fas2.PEST-} P{UAS-mCD8::GFP.L} P{UAS-nvy.T} P{UAS-Sema-1a.Δcyto} P{UAS-sema-I.Y}
Genes (6)
	Ecol\lacZ Fas2 Mmus\Cd8a nvy Scer\GAL4 Sema-1a
Insertions (1)
	P{GawB}elav^C155