Reference Report

Reference
Citation	Micchelli, C.A., Perrimon, N. (2006). Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439(7075): 475--479. (Export to RIS)
FlyBase ID	FBrf0191249
Publication Type	Research paper
PubMed ID	16340959
PubMed Abstract	Adult stem cells maintain organ systems throughout the course of life and facilitate repair after injury or disease. A fundamental property of stem and progenitor cell division is the capacity to retain a proliferative state or generate differentiated daughter cells; however, little is currently known about signals that regulate the balance between these processes. Here, we characterize a proliferating cellular compartment in the adult Drosophila midgut. Using genetic mosaic analysis we demonstrate that differentiated cells in the epithelium arise from a common lineage. Furthermore, we show that reduction of Notch signalling leads to an increase in the number of midgut progenitor cells, whereas activation of the Notch pathway leads to a decrease in proliferation. Thus, the midgut progenitor's default state is proliferation, which is inhibited through the Notch signalling pathway. The ability to identify, manipulate and genetically trace cell lineages in the midgut should lead to the discovery of additional genes that regulate stem and progenitor cell biology in the gastrointestinal tract.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (11)
	Avic\GFP^Scer\UAS.cUa Ecol\lacZ^{Ddc.be2.E(spl).m8} N^55e11 N^264-47 N^{dsRNA.P.Scer\UAS} N^{int.G.Scer\UAS} N^l1N-ts1 N^nd-1 Scer\GAL4^esg-NP5130 Scer\GAL80^ts.αTub84B sqh^{RLC.T:Avic\GFP-S65T}
Constructs (6)
	P{Ddc.E(spl)-lacZ.Gbe.m8} P{sqh-GFP.RLC} P{tubP-GAL80^ts} P{UAS-GFP.U} P{UAS-N.dsRNA.P} P{UAS-N.intra.G}
Genes (10)
	Avic\GFP Ecol\lacZ esg His3 N pros Scer\GAL4 Scer\GAL80 sqh T:Avic\GFP
Insertions (1)
	P{GawB}NP5130