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Mukherjee, A., Veraksa, A., Bauer, A., Rosse, C., Camonis, J., Artavanis-Tsakonas, S. (2005). Regulation of Notch signalling by non-visual beta-arrestin.  Nat. Cell Biol. 7(12): 1191--1201.
FlyBase ID
FBrf0191265
Publication Type
Research paper
Abstract

Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling mechanism that depends on the ability of the non-visual beta-arrestin, Kurtz (Krz), to influence the degradation and, consequently, the function of the Notch receptor. We identified Krz as a binding partner of a known Notch-pathway modulator, Deltex (Dx), and demonstrated the existence of a trimeric Notch-Dx-Krz protein complex. This complex mediates the degradation of the Notch receptor through a ubiquitination-dependent pathway. Our results establish a novel mode of regulation of Notch signalling and define a new function for non-visual beta-arrestins.

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PubMed Central ID
Related Publication(s)
Review

STKE: Β-Arrestin regulated Notch abundance.
Anonymous, 2006, Science 310(5756): 1872 [FBrf0198693]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference
    Alleles (13)
    Gene Groups (1)
    Genes (4)
    Physical Interactions (5)
    Cell Lines (2)
    Natural transposons (1)
    Insertions (2)
    Experimental Tools (3)
    Transgenic Constructs (3)