Reference Report

Reference
Citation	Liu, L.P., Ni, J.Q., Shi, Y.D., Oakeley, E.J., Sun, F.L. (2005). Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat. Genet. 37(12): 1361--1366. (Export to RIS)
FlyBase ID	FBrf0191273
Publication Type	Research paper
PubMed ID	16258543
PubMed Abstract	Drosophila melanogaster heterochromatin protein 1 (HP1a or HP1) is believed to be involved in active transcription, transcriptional gene silencing and the formation of heterochromatin. But little is known about the function of HP1 during development. Using a Gal4-induced RNA interference system, we showed that conditional depletion of HP1 in transgenic flies resulted in preferential lethality in male flies. Cytological analysis of mitotic chromosomes showed that HP1 depletion caused sex-biased chromosomal defects, including telomere fusions. The global levels of specific histone modifications, particularly the hallmarks of active chromatin, were preferentially increased in males as well. Expression analysis showed that approximately twice as many genes were specifically regulated by HP1 in males than in females. Furthermore, HP1-regulated genes showed greater enrichment for HP1 binding in males. Taken together, these results indicate that HP1 modulates chromosomal integrity, histone modifications and transcription in a sex-specific manner.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Genet.
Title	Nature Genetics
Publication Year	1992-
ISBN/ISSN	1061-4036 1546-1718
Data from Reference
Alleles (6)
	BacA\p35^Scer\UAS.cHa Scer\GAL4^Act.PU Scer\GAL4^en-e16E Scer\GAL4^ey.PH Su(var)205^{dsRNA.Sym.Scer\UAS} w^+mC
Constructs (3)
	P{GAL4-ey.H} P{Sym-UAS-Su(var)205} P{UAS-p35.H}
Genes (48)
	BacA\p35 CG5790 CG6901 CG8043 CG9920 CG12470 CG12699 CG15109 CG15208 CG17377 CG17386 CG31087 CG31624 CG31804 CG44245 Cks30A CycB3 dally Drep-4 e E(spl)m7-HLH E(spl)mα-BFM en fzy geminin Glt Glycogenin Gpdh His3 His4 hoe1 IA-2 LysX Mcm6 msl-1 mus209 pim rst Scer\GAL4 S-Lap1 sm stai Su(var)205 Tm2 vis W w αTry
Insertions (5)
	P{en2.4-GAL4}e16E P{Sym-UAS-Su(var)205}1-2 P{Sym-UAS-Su(var)205}1-11 P{Sym-UAS-Su(var)205}1-21 P{Sym-UAS-Su(var)205}1-31
Natural transposons (1)
	P-element