Reference Report

Reference
Citation	Brankatschk, M., Dickson, B.J. (2006). Netrins guide Drosophila commissural axons at short range. Nat. Neurosci. 9(2): 188--194. (Export to RIS)
FlyBase ID	FBrf0191277
Publication Type	Research paper
PubMed ID	16429137
PubMed Abstract	Netrins are secreted axon guidance molecules required for commissure formation in a wide range of animal species, including Caenorhabditis elegans, Drosophila melanogaster and mice. They are generally thought to function as chemoattractants, acting at a distance to direct commissural axon growth toward the midline of the central nervous system. We show here, however, that D. melanogaster commissural axons still orient normally and reach the midline even in the complete absence of netrins, though some of them fail to cross the midline. Tethering endogenous netrin to the membrane selectively disrupts its long-range but not short-range activity, yet still allows normal commissure formation. We therefore propose that netrins act in commissural axon guidance as short-range cues that promote midline crossing, not as long-range chemoattractants.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Aberrations (1)
	Df(1)NetAB^Δ
Alleles (9)
	Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} NetA^Δ NetB^{KI.T:Hsap\MYC} NetB^{KI.T:SV5\V5,T:Zzzz\TM,T:Hsap\MYC} NetB^Δ Scer\GAL4^ato-NP6558 Scer\GAL4^eg-Mz360 Scer\GAL4^insc-Mz1407 unc-5^Scer\UAS.cKa
Constructs (2)
	P{UAS-mCD8::GFP.L} P{UAS-unc-5.K}
Genes (10)
	CG5321 Fas2 Mmus\Cd8a NetA NetB Scer\GAL4 T:Hsap\MYC T:SV5\V5 T:Zzzz\TM unc-5
Insertions (6)
	P{GawB}ato^NP6558 P{GawB}eg^Mz360 P{GawB}insc^Mz1407 P{GawB}NP6098 P{GT1}NetA^BG02298 P{SUPor-P}CG9413^KG04428