Reference Report

Reference
Citation	Sato, M., Umetsu, D., Murakami, S., Yasugi, T., Tabata, T. (2006). DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. Nat. Neurosci. 9(1): 67--75. (Export to RIS)
FlyBase ID	FBrf0191282
Publication Type	Research paper
PubMed ID	16369482
PubMed Abstract	In Drosophila melanogaster, the axons of retinal photoreceptor cells extend to the first optic ganglion, the lamina, forming a topographic representation. Here we show that DWnt4, a secreted protein of the Wnt family, is the ventral cue for the lamina. In DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina. DWnt4 was normally expressed in the ventral half of the developing lamina and DWnt4 protein was detected along ventral retinal axons. Dfrizzled2 and dishevelled, respectively, encode a receptor and a signaling molecule required for Wnt signaling. Mutations in both genes caused DWnt4-like defects, and both genes were autonomously required in the retina, suggesting a direct role of DWnt4 in retinal axon guidance. In contrast, iroquois homeobox genes are the dorsal cues for the retina. Dorsal axons accumulated DWnt4 and misprojected to the ventral lamina in iroquois mutants; the phenotype was suppressed in iroquois Dfrizzled2 mutants, suggesting that iroquois may attenuate the competence of Dfrizzled2 to respond to DWnt4.
DOI
Related Publication(s)
Erratum	DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system (vol 9, pg 67, 2006). Sato et al., 2006, Nat. Neurosci. 9(2): 292 [FBrf0191283]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Aberrations (4)
	Df(2L)DE Df(3L)fz2 Df(3L)fz-D21 Df(3L)iro-DFM3
Alleles (28)
	ara^DFM3 arm^ΔN.Scer\UAS Avic\GFP^{Scer\UAS.T:SV40\nls2} bsk^DN.Scer\UAS Btau\MAPT^{ato.hs.T:Hsap\MYC} caup^DFM3 dsh⁴ dsh^Scer\UAS.cAa dsh^{ΔDEP+.Scer\UAS} Ecol\lacZ^{bi.T:Btau\MAPT} Ecol\lacZ^{ro.T:Btau\MAPT} fz2^C1 fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} fz³⁰ hep^r75 l(2)SH0553^SH0553 mirr^DFM3 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} pan^ΔN.Scer\UAS puc^Scer\UAS.cMa Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^NP6099 W^GMR.PU Wnt4^C1 Wnt4^EMS23 Wnt4^P23 Wnt4^Scer\UAS.WT
Constructs (16)
	P{ato-tau-myc} P{bi-taulacZ.N} P{GAL4-ey.H} P{GAL4-ninaE.GMR} P{GMR-W.U} P{ro.lacZ-tau.G} P{UAS-arm.ΔN} P{UAS-bsk.DN} P{UAS-dsh.A} P{UAS-dsh.ΔDEP+} P{UAS-fz2(ECD)-GPI} P{UAS-GFP.nls} P{UAS-mCD8::GFP.L} P{UAS-pan.dTCFΔN} P{UAS-puc.M} P{UAS-Wnt4.WT}
Genes (18)
	ara arm Avic\GFP bsk Btau\MAPT caup dsh Ecol\lacZ fz fz2 hep mirr Mmus\Cd8a pan puc Scer\GAL4 W Wnt4
Insertions (1)
	P{GawB}NP6099
Natural transposons (1)
	P-element