Reference Report

Reference
Citation	Chotard, C., Leung, W., Salecker, I. (2005). glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Neuron 48(2): 237--251. (Export to RIS)
FlyBase ID	FBrf0191311
Publication Type	Research paper
PubMed ID	16242405
PubMed Abstract	The transcription factors Glial cells missing (Gcm) and Gcm2 are known to play a crucial role in promoting glial-cell differentiation during Drosophila embryogenesis. Our findings reveal a central function for gcm genes in regulating neuronal development in the postembryonic visual system. We demonstrate that Gcm and Gcm2 are expressed in both glial and neuronal precursors within the optic lobe. Removal of gcm and gcm2 function shows that the two genes act redundantly and are required for the formation of a subset of glial cells. They also cell-autonomously control the differentiation and proliferation of specific neurons. We show that the transcriptional regulator Dachshund acts downstream of gcm genes and is required to make lamina precursor cells and lamina neurons competent for neuronal differentiation through regulation of epidermal growth factor receptor levels. Our findings further suggest that gcm genes regulate neurogenesis through collaboration with the Hedgehog-signaling pathway.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(2L)200 Df(2L)gcm2
Alleles (22)
	Avic\GFP^Ubi-p63E.PD ci^{Scer\UAS.T:Hsim\VP16} CycE^AR95 dac¹ Ecol\lacZ^gcm-rA87 Ecol\lacZ^HLHmδ.0.5 Ecol\lacZ^{ro.T:Btau\MAPT} Ecol\lacZ^Scer\UAS.cUa eya¹ gcm2^Scer\UAS.cCa gcm^rA87.C gcm^Scer\UAS.cJa gcm^ΔP1 hh^bar3 lama^A8C Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^Act5C.PI Scer\GAL4^elav-C155 Scer\GAL4^gcm-rA87.C Scer\GAL4^lama-A8 Scer\GAL4^αTub84B.PL Scer\GAL80^ey.3.5
Constructs (12)
	P{Act5C-GAL4} P{ey-GAL80.3.5} P{GawB} P{HLHmδ-lacZ.0.5} P{ro.lacZ-tau.G} P{tubP-GAL4} P{UAS-ci::VP16} P{UAS-gcm2.C} P{UAS-gcm.J} P{UAS-lacZ.U} P{UAS-mCD8::GFP.L} P{Ubi-GFP.D}
Genes (20)
	Avic\GFP chp ci CycE dac decay Ecol\lacZ Egfr elav eya gcm gcm2 hh His3 lama mira Mmus\Cd8a repo Scer\GAL4 Scer\GAL80
Insertions (5)
	P{GawB}A8C P{GawB}elav^C155 P{GawB}gcm^rA87.C P{PZ}A8 P{PZ}gcm^rA87
Natural transposons (1)
	P-element