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Lear, B.C., Merrill, C.E., Lin, J.M., Schroeder, A., Zhang, L., Allada, R. (2005). A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.  Neuron 48(2): 221--227.
FlyBase ID
FBrf0191322
Publication Type
Research paper
Abstract

The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila. Here we identify mutants (groom-of-PDF; gop) that display phase-advanced evening activity and poor free-running rhythmicity, phenocopying pdf mutants. In gop mutants, a spontaneous retrotransposon disrupts a coding exon of a G protein-coupled receptor, CG13758. Disruption of the receptor is accompanied by phase-advanced oscillations of the core clock protein PERIOD. Moreover, effects on circadian timing induced by perturbation of PDF neurons require gop. Yet PDF oscillations themselves remain robust in gop mutants, suggesting that GOP acts downstream of PDF. gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila.

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PubMed Central ID
Related Publication(s)
Note

Neurobiology: Calling time.
Anonymous, 2005, Nature 437(7063): 1211 [FBrf0191494]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (8)
    Alleles (5)
    Genes (14)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (3)