Reference Report

Reference
Citation	Shinza-Kameda, M., Takasu, E., Sakurai, K., Hayashi, S., Nose, A. (2006). Regulation of layer-specific targeting by reciprocal expression of a cell adhesion molecule, capricious. Neuron 49(2): 205--213. (Export to RIS)
FlyBase ID	FBrf0191328
Publication Type	Research paper
PubMed ID	16423695
PubMed Abstract	Layer-specific innervation is a major form of synaptic targeting in the central nervous system. In the Drosophila visual system, photoreceptors R7 and R8 connect to targets in distinct layers of the medulla, a ganglion of the optic lobe. We show here that Capricious (CAPS), a transmembrane protein with leucine-rich repeats (LRRs), is a layer-specific cell adhesion molecule that regulates photoreceptor targeting in the medulla. During the period of photoreceptor targeting, caps is specifically expressed in R8 and its target layer but not in R7 or its recipient layer. caps loss-of-function mutations cause local targeting errors by R8 axons, including layer change. Conversely, ectopic expression of caps in R7 redirects R7 axons to terminate in the CAPS-positive R8 recipient layer. CAPS promotes homophilic cell adhesion in transfected S2 cells. These results suggest that CAPS regulates layer-specific targeting by mediating specific axon-target interaction.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (11)
	caps^65.2 caps^C18fs caps^Scer\UAS.cSa Ecol\lacZ^caps-E2-3-27 Ecol\lacZ^{Rh4.T:Btau\MAPT} Ecol\lacZ^{Rh5.T:Btau\MAPT} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^bi-omb-Gal4 Scer\GAL4^caps-NP3294 Scer\GAL4^GMR.PY Scer\GAL4^hs.2sev
Constructs (6)
	P{GAL4-Hsp70.sev} P{GMR-GAL4.Y} P{Rh4-taulacZ.N} P{Rh5-tau-lacZ} P{UAS-caps.S} P{UAS-mCD8::GFP.L}
Genes (9)
	boss caps chp Ecol\lacZ Lar Mmus\Cd8a Scer\GAL4 sens T:Btau\MAPT
Insertions (3)
	P{GAL4}bi^omb-Gal4 P{GawB}caps^NP3294 P{lacW}caps^E2-3-27
Natural transposons (1)
	P-element
Transcripts (4)
	Ecol\lacZ^caps-E2-3-27RA Ecol\lacZ^{Rh5.T:Btau\MAPT}RA Scer\GAL4^bi-omb-Gal4RA Scer\GAL4^caps-NP3294RA