Reference Report

Reference
Citation	Fayyazuddin, A., Zaheer, M.A., Hiesinger, P.R., Bellen, H.J. (2006). The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. PLoS Biol. 4(3): e63. (Export to RIS)
FlyBase ID	FBrf0191369
Publication Type	Research paper
PubMed ID	16494528
PubMed Abstract	Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the Dalpha7 nicotinic acetylcholine receptor (nAChR) of Drosophila shows that it is required for the giant fiber-mediated escape behavior. The Dalpha7 protein is enriched in the dendrites of the giant fiber, and electrophysiological analysis of the giant fiber circuit showed that sensory input to the giant fiber is disrupted, as is transmission at an identified cholinergic synapse between the peripherally synapsing interneuron and the dorsal lateral muscle motor neuron. Moreover, we found that gfA1, a mutation identified in a screen for giant fiber defects more than twenty years ago, is an allele of Dalpha7. Therefore, a combination of behavioral, electrophysiological, anatomical, and genetic data indicate an essential role for the Dalpha7 nAChR in giant fiber-mediated escape in Drosophila.
DOI
Related Publication(s)
Review	Jumping for dear life with a giant neuron and a single receptor. Chanut, 2006, PLoS Biol. 4(3): e93 [FBrf0200140]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	PLoS Biol.
Title	PLoS Biology
Publication Year	2003-
ISBN/ISSN	1545-7885 1544-9173
Data from Reference
Alleles (13)
	gfA¹ gfA^PΔ5 gfA^PΔ14G gfA^PΔ41 gfA^PΔEY5 gfA^PΔEY6 gfA^PΔL1 gfA^Scer\UAS.cFa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^c17 Scer\GAL4^gfA-3295 Scer\GAL4^OK307 w^+mC
Constructs (3)
	P{GawB} P{UAS-gfA.F} P{UAS-mCD8::GFP.L}
Genes (4)
	gfA Mmus\Cd8a Scer\GAL4 w
Insertions (6)
	P{EPgy2}gfA^EY10801 P{GAL4}c17 P{GawB}3295 P{GawB}NP0515 P{GawB}OK307 P{SUPor-P}KG03295
Natural transposons (1)
	P-element