Reference Report

Reference
Citation	Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Haeder, T., Hilfiker, A., Broenner, G., Ephrussi, A., Rorth, P., Cohen, S.M., Fellert, S., Chung, H.R., Piepenburg, O., Schaefer, U., Jaeckle, H., Vorbrueggen, G. (2005). Gain-of-function screen for genes that affect Drosophila muscle pattern formation. PLoS Genet. 1(4): e55. (Export to RIS)
FlyBase ID	FBrf0191391
Publication Type	Research paper
PubMed ID	16254604
PubMed Abstract	This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle pattern formation. We designed a UAS/GAL4 system to drive GAL4-responsive expression of the EP-targeted genes in developing apodeme cells to which migrating myotubes finally attach and in an intrasegmental pattern of cells that serve myotubes as a migration substrate on their way towards the apodemes. The results suggest that misexpression of more than 1.5% of the Drosophila genes can interfere with proper myotube guidance and/or muscle attachment. In addition to factors already known to participate in these processes, we identified a number of enzymes that participate in the synthesis or modification of protein carbohydrate side chains and in Ubiquitin modifications and/or the Ubiquitin-dependent degradation of proteins, suggesting that these processes are relevant for muscle pattern formation.
DOI	10.1371/journal.pgen.0010055
Related Publication(s)
Supplementary material	Table S1. [FBrf0208296] Table S2. [FBrf0208297]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Genet.
Title	PLoS Genetics
Publication Year	2005-
ISBN/ISSN	1553-7404 1553-7390
Data from Reference
Alleles (11)
	CG31710^EP2160 CG32436^EPg4-38 Ecol\lacZ^Scer\UAS.cUa esg^L2 mfrn^EPg4-38 nmo^EPg4-38 Parg^EPg4-38 Scer\GAL4^sr-239.ΔPan Scer\GAL4^sr-239 Sdc²³ SmG^EPg4-38
Constructs (5)
	P{EP} P{EPg} P{GawB} P{Mae-UAS.6.11} P{UAS-lacZ.U}
Genes (42)
	Adk1 Cda5 CG9030 CG14052 CG31710 CG32436 CG34459 CG34460 CG42327 chic CycE dysc Ecol\lacZ eff esg GNBP3 jvl kat80 Kdm2 mfrn Mhc mwh nmo Oda Pabp2 Parg pxb pyd rdgBβ RpL18A Scer\GAL4 Sdc sfl shn SmG sr Tango13 Tl Tsp42Ee twe tx Uba1
Insertions (504)
	All Insertions relating to this reference
Libraries/Collections (2)
	TI_set_P{EPg}.HP TI_set_P{Mae-UAS.6.11}.DP