A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Reference Report

Reference
Citation Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Haeder, T., Hilfiker, A., Broenner, G., Ephrussi, A., Rorth, P., Cohen, S.M., Fellert, S., Chung, H.R., Piepenburg, O., Schaefer, U., Jaeckle, H., Vorbrueggen, G. (2005). Gain-of-function screen for genes that affect Drosophila muscle pattern formation.  PLoS Genet. 1(4): e55. (Export to RIS)
FlyBase ID FBrf0191391
Publication Type Research paper
PubMed ID 16254604
PubMed Abstract This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle pattern formation. We designed a UAS/GAL4 system to drive GAL4-responsive expression of the EP-targeted genes in developing apodeme cells to which migrating myotubes finally attach and in an intrasegmental pattern of cells that serve myotubes as a migration substrate on their way towards the apodemes. The results suggest that misexpression of more than 1.5% of the Drosophila genes can interfere with proper myotube guidance and/or muscle attachment. In addition to factors already known to participate in these processes, we identified a number of enzymes that participate in the synthesis or modification of protein carbohydrate side chains and in Ubiquitin modifications and/or the Ubiquitin-dependent degradation of proteins, suggesting that these processes are relevant for muscle pattern formation.
DOI 10.1371/journal.pgen.0010055
Related Publication(s)
Supplementary material Table S1. [FBrf0208296]

Table S2. [FBrf0208297]

hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Associated Information
Comments
Associated Files
hide Other Information
Secondary IDs
Language of Publication English
Additional Languages of Abstract
Also Published As
hide Parent Publication
Publication Type Journal
Abbreviation PLoS Genet.
Title PLoS Genetics
Publication Year 2005-
ISBN/ISSN 1553-7404 1553-7390
hide Data from Reference
hideAlleles (11)
hideConstructs (5)
hideGenes (42)
hideInsertions (504)
hideLibraries/Collections (2)