A Database of Drosophila Genes & Genomes

 

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Citation Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Haeder, T., Hilfiker, A., Broenner, G., Ephrussi, A., Rorth, P., Cohen, S.M., Fellert, S., Chung, H.R., Piepenburg, O., Schaefer, U., Jaeckle, H., Vorbrueggen, G. (2005). Gain-of-function screen for genes that affect Drosophila muscle pattern formation.  PLoS Gen. 1(4): e55.
FlyBase ID FBrf0191391
Type of publication Research paper
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PubMed ID 16254604
PubMed Abstract This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle pattern formation. We designed a UAS/GAL4 system to drive GAL4-responsive expression of the EP-targeted genes in developing apodeme cells to which migrating myotubes finally attach and in an intrasegmental pattern of cells that serve myotubes as a migration substrate on their way towards the apodemes. The results suggest that misexpression of more than 1.5% of the Drosophila genes can interfere with proper myotube guidance and/or muscle attachment. In addition to factors already known to participate in these processes, we identified a number of enzymes that participate in the synthesis or modification of protein carbohydrate side chains and in Ubiquitin modifications and/or the Ubiquitin-dependent degradation of proteins, suggesting that these processes are relevant for muscle pattern formation.
Biosis 2006.215795
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Language of publication English
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Abbreviation PLoS Gen.
Title PLoS Genetics
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Volume range 1-
Year range 2005-
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Place of publication San Francisco, CA
Language of publication English
ISBN/ISSN 1553-7404 1553-7390
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