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Citation
Katanaev, V.L., Tomlinson, A. (2006). Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 103(17): 6524--6529.
FlyBase ID
FBrf0191444
Publication Type
Research paper
Abstract

During asymmetric division, a cell polarizes and differentially distributes components to its opposite ends. The subsequent division differentially segregates the two component pools to the daughters, which thereby inherit different developmental directives. In Drosophila sensory organ precursor cells, the localization of Numb protein to the cell's anterior cortex is a key patterning event and is achieved by the combined action of many proteins, including Pins, which itself is localized anteriorly. Here, a role is described for the trimeric G protein Go in the anterior localization of Numb and daughter cell fate specification. Go is shown to interact with Pins. In addition to a role in recruiting Numb to an asymmetric location in the cell's cortex, Go transduces a signal from the Frizzled receptor that directs the position in which the complex forms. Thus, Go likely integrates the signaling that directs the formation of the complex with the signaling that directs where the complex forms.

PubMed ID
PubMed Central ID
PMC1436022 (PMC) (EuropePMC)
Related Publication(s)
Review

Going for the correct orientation.
Chin and Yeston, 2006, Science 312(5775): 817 [FBrf0198701]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference