Open Close
Reference
Citation
Kusama, S., Ueda, R., Suda, T., Nishihara, S., Matsuura, E.T. (2006). Involvement of Drosophila Sir2-like genes in the regulation of life span.  Genes & Genet. Systems 81(5): 341--348.
FlyBase ID
FBrf0192070
Publication Type
Research paper
Abstract

In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes & Genet. Systems
    Title
    Genes & Genetic Systems
    Publication Year
    1996-
    ISBN/ISSN
    1341-7568
    Data From Reference
    Alleles (5)
    Genes (4)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (5)