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| Citation | Kaneko, T., Yano, T., Aggarwal, K., Lim, J.H., Ueda, K., Oshima, Y., Peach, C., Erturk-Hasdemir, D., Goldman, W.E., Oh, B.H., Kurata, S., Silverman, N. (2006). PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat. Immunol. 7(7): 715--723. (Export to RIS) | ||
| FlyBase ID | FBrf0192084 | ||
| Publication Type | Research paper | ||
| PubMed ID | 16767093 | ||
| PubMed Abstract | Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-kappaB through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition. | ||
| DOI | 10.1038/ni1356 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nat. Immunol. | ||
| Title | Nature Immunology | ||
| Publication Year | 2000- | ||
| ISBN/ISSN | 1529-2908 1529-2916 | ||
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Data from Reference
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| Genes (6)
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