Reference Report

Reference
Citation	Mulinari, S., Hacker, U., Castillejo-Lopez, C. (2006). Expression and regulation of Spatzle-processing enzyme in Drosophila. FEBS Lett. 580(22): 5406--5410. (Export to RIS)
FlyBase ID	FBrf0192112
Publication Type	Research paper
PubMed ID	16996061
PubMed Abstract	The Drosophila melanogaster Toll receptor controls embryonic dorsal-ventral axis formation and is crucial for the innate immune response. In both cases, Toll is activated by the enzymatically cleaved form of its ligand Spätzle (Spz). During axis formation, Spz is cleaved by the maternally provided serine protease Easter while the Spätzle-processing enzyme (SPE) activates Spz after infection. We confirm the role of SPE in immunity and show that it is a zygotic gene specifically expressed in immune tissues implying that the dual activation of Spz is achieved by differential spatiotemporal expression of two similar but distinct serine proteases.
DOI	10.1016/j.febslet.2006.09.009
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Language of Publication	English
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Publication Type	Journal
Abbreviation	FEBS Lett.
Title	FEBS Letters
Publication Year	1968-
ISBN/ISSN	0014-5793
Data from Reference
Alleles (14)
	CG3505^{dsRNA.Scer\UAS.cMa} CG6639^{dsRNA.Scer\UAS.cMa} CG9733^{dsRNA.Scer\UAS.cMa} key¹ Rel^E20 Scer\GAL4^Act5C.PI Scer\GAL4^unspecified Ser7^{dsRNA.Scer\UAS.cMa} Sp7^{dsRNA.Scer\UAS.cMa} SPE^{dsRNA.Scer\UAS.cMa} spz⁴ Tl⁸ tub¹ tub²
Constructs (8)
	P{Act5C-GAL4} P{GAL4} P{UAS-CG3505.dsRNA.M} P{UAS-CG6639.dsRNA.M} P{UAS-CG9733.dsRNA.M} P{UAS-Ser7.dsRNA.M} P{UAS-Sp7.dsRNA.M} P{UAS-SPE.dsRNA.M}
Genes (15)
	CG3505 CG6639 CG9733 Dpt Drs hep key Rel Scer\GAL4 Ser7 Sp7 SPE spz Tl tub
Natural transposons (1)
	P-element