Reference Report

Reference
Citation	Shang, Y., Claridge-Chang, A., Sjulson, L., Pypaert, M., Miesenbock, G. (2007). Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe. Cell 128(3): 601--612. (Export to RIS)
FlyBase ID	FBrf0192172
Publication Type	Research paper
PubMed ID	17289577
PubMed Abstract	Conflicting views exist of how circuits of the antennal lobe, the insect equivalent of the olfactory bulb, translate input from olfactory receptor neurons (ORNs) into projection-neuron (PN) output. Synaptic connections between ORNs and PNs are one-to-one, yet PNs are more broadly tuned to odors than ORNs. The basis for this difference in receptive range remains unknown. Analyzing a Drosophila mutant lacking ORN input to one glomerulus, we show that some of the apparent complexity in the antennal lobe's output arises from lateral, interglomerular excitation of PNs. We describe a previously unidentified population of cholinergic local neurons (LNs) with multiglomerular processes. These excitatory LNs respond broadly to odors but exhibit little glomerular specificity in their synaptic output, suggesting that PNs are driven by a combination of glomerulus-specific ORN afferents and diffuse LN excitation. Lateral excitation may boost PN signals and enhance their transmission to third-order neurons in a mechanism akin to stochastic resonance.
DOI	10.1016/j.cell.2006.12.034
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	Df(2L)dp-79b Dp(2;2)dpp^d21 Tp(2;2)dpp^d21
Alleles (17)
	Avic\GFP^{pHluorinSE.Orco.T:Mmus\Vamp2} Avic\GFP^{pHluorinSE.Scer\UAS.T:Mmus\Vamp2} Disc\RFP^Cha.7347 Disc\RFP^Or22a.8197 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} rpr^Scer\UAS.cYa Scer\GAL4^{exba-krasavietz} Scer\GAL4^GH146 Scer\GAL4^GH298 Scer\GAL4^KL78 Scer\GAL4^KL107 Scer\GAL4^lilli-189Y Scer\GAL4^Or22a.8010 Scer\GAL4^Or47a.8.239 Scer\GAL4^Or92a.PW Scer\GAL4^{Orco.2.642.T:Hsim\VP22} T:Avic\GFP^pHluorinSE
Constructs (10)
	P{Cha-dsRed.7347} P{Or22a-dsRed.8197} P{Or22a-GAL4.8010} P{Or47a-GAL4.8.239} P{Or92a-GAL4.W} P{Orco-GAL4.W} P{Orco-spH.7.087} P{UAS-mCD8::GFP.L} P{UAS-rpr.Y} P{UAS-synapto-pHluorinSE.Vamp2}
Genes (11)
	Avic\GFP Cha Disc\RFP exba lilli Mmus\Cd8a Or22a Orco rpr Scer\GAL4 T:Mmus\Vamp2
Insertions (6)
	P{GAL4}exba^krasavietz P{GAL4}KL78 P{GawB}GH146 P{GawB}GH298 P{GawB}KL107 P{GawB}lilli^189Y
Natural transposons (1)
	P-element
Transcripts (10)
	Disc\RFP^Cha.7347RA Disc\RFP^Or22a.8197RA Scer\GAL4^{exba-krasavietz}RA Scer\GAL4^GH146RA Scer\GAL4^GH298RA Scer\GAL4^KL78RA Scer\GAL4^KL107RA Scer\GAL4^lilli-189YRA Scer\GAL4^Or22a.8010RA Scer\GAL4^{Orco.2.642.T:Hsim\VP22}RA