Reference Report

Reference
Citation	Wang, D., Qian, L., Xiong, H., Liu, J., Neckameyer, W.S., Oldham, S., Xia, K., Wang, J., Bodmer, R., Zhang, Z. (2006). Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 103(36): 13520--13525. (Export to RIS)
FlyBase ID	FBrf0192173
Publication Type	Research paper
PubMed ID	16938835
PubMed Abstract	Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder. Mutations in the PINK1 gene are linked to the autosomal recessive early onset familial form of PD. The physiological function of PINK1 and pathological abnormality of PD-associated PINK1 mutants are largely unknown. We here show that inactivation of Drosophila PINK1 (dPINK1) using RNAi results in progressive loss of dopaminergic neurons and in ommatidial degeneration of the compound eye, which is rescued by expression of human PINK1 (hPINK1). Expression of human SOD1 suppresses neurodegeneration induced by dPINK1 inactivation. Moreover, treatment of dPINK1 RNAi flies with the antioxidants SOD and vitamin E significantly inhibits ommatidial degeneration. Thus, dPINK1 plays an essential role in maintaining neuronal survival by preventing neurons from undergoing oxidative stress, thereby suggesting a potential mechanism by which a reduction in PINK1 function leads to PD-associated neurodegeneration.
DOI	10.1073/pnas.0604661103
Related Publication(s)
Review	Antioxidants put Parkinson flies back in the PINK. Bier, 2006, Proc. Natl. Acad. Sci. U.S.A. 103(36): 13269--13270 [FBrf0195074]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (11)
	Ecol\lacZ^Scer\UAS.cUa Hsap\PINK1^{G309D.Scer\UAS.T:Zzzz\FLAG} Hsap\PINK1^{Scer\UAS.T:Zzzz\FLAG} Hsap\SOD1^Scer\UAS.cPa Pink1^{dsRNA.Scer\UAS.cWa} Scer\GAL4^da.G32 Scer\GAL4^Ddc.PL Scer\GAL4^elav.PLu Scer\GAL4^GMR.PF th^Scer\UAS.cHa w^+mC
Constructs (10)
	P{Ddc-GAL4.L} P{GAL4-da.G32} P{GAL4-elav.L} P{GAL4-ninaE.GMR} P{UAS-DIAP1.H} P{UAS-Hsap\SOD1.P} P{UAS-lacZ.U} P{UAS-Pink1.dsRNA} P{UAS-PINK1.FLAG} P{UAS-PINK1.G309D.FLAG}
Genes (13)
	Act5C Act42A dlg1 Ecol\lacZ elav Hsap\PINK1 Hsap\SOD1 Pink1 ple Scer\GAL4 T:Zzzz\FLAG th w
Natural transposons (1)
	P-element