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Reference Report
| Reference | |||
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| Citation | Stabell, M., Bjørkmo, M., Aalen, R.B., Lambertsson, A. (2006). The Drosophila SET domain encoding gene dEset is essential for proper development. Hereditas 143(2006): 177--188. (Export to RIS) | ||
| FlyBase ID | FBrf0192183 | ||
| Publication Type | Research paper | ||
| PubMed ID | 17362353 | ||
| PubMed Abstract | We have identified dEset, the fly homolog of human SETDB1 and mouse ESET histone lysine methyltransferases (HKMTases) that methylates the lysine 9 residue of histone 3 (H3-K9) and negatively regulates transcription of target genes. By using spatio-temporal RNA interference we show that dEset is required at several stages of development coinciding with ecdysone pulses, possibly as a repressor of transcription of target genes. Several interacting partners, for example USP, spire, and cut up were identified in a yeast two-hybrid screen. The spatio-temporal expression profiles of dEset and its potential partners suggest that they may act together or even in a larger complex. | ||
| DOI | 10.1111/j.2006.0018-0661.01970.x | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Hereditas | ||
| Title | Hereditas | ||
| Publication Year | 1920- | ||
| ISBN/ISSN | 0018-0661 | ||
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Data from Reference
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| Alleles (6)
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| Constructs (2)
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| Genes (13)
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| Insertions (3)
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| Natural transposons (1)
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