|Citation||Stabell, M., Bjørkmo, M., Aalen, R.B., Lambertsson, A. (2006). The Drosophila SET domain encoding gene dEset is essential for proper development. Hereditas 143(2006): 177--188. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||We have identified dEset, the fly homolog of human SETDB1 and mouse ESET histone lysine methyltransferases (HKMTases) that methylates the lysine 9 residue of histone 3 (H3-K9) and negatively regulates transcription of target genes. By using spatio-temporal RNA interference we show that dEset is required at several stages of development coinciding with ecdysone pulses, possibly as a repressor of transcription of target genes. Several interacting partners, for example USP, spire, and cut up were identified in a yeast two-hybrid screen. The spatio-temporal expression profiles of dEset and its potential partners suggest that they may act together or even in a larger complex.|
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|Language of Publication||English|
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|Natural transposons (1)|