|Citation||Williams, K.D., Busto, M., Suster, M.L., So, A.K.C., Ben-Shahar, Y., Leevers, S.J., Sokolowski, M.B. (2006). Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103(43): 15911--15915. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.|
Anonymous, 2006, Science 314(5801): 895 [FBrf0200010]
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|Language of Publication||English|
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|Also Published As|
|Abbreviation||Proc. Natl. Acad. Sci. U.S.A.|
|Title||Proceedings of the National Academy of Sciences of the United States of America|
|Data from Reference|
|Natural transposons (1)|