Reference Report

Reference
Citation	Williams, K.D., Busto, M., Suster, M.L., So, A.K.C., Ben-Shahar, Y., Leevers, S.J., Sokolowski, M.B. (2006). Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103(43): 15911--15915. (Export to RIS)
FlyBase ID	FBrf0192255
Publication Type	Research paper
PubMed ID	17043223
PubMed Abstract	This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.
DOI	10.1073/pnas.0604592103
Related Publication(s)
Review	Timing out. Anonymous, 2006, Science 314(5801): 895 [FBrf0200010]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
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Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (3)
	Df(3R)H-B79 Df(3R)Pi3K92E^A Df(3R)Pi3K92E-B
Alleles (9)
	Ecol\lacZ^{Scer\UAS.O.T:Btau\MAPT} H^D179 H^HBS Pi3K92E^+t14.7 Pi3K92E^A Pi3K92E^B Pi3K92E^Scer\UAS.cWa Scer\GAL4^elav-C155 Scer\GAL4^GMR.PF
Constructs (5)
	P{GAL4-ninaE.GMR} P{HBS} P{Pi3K92E.14.7} P{UAS-Dp110.W} P{UAS-tau-lacZ.O}
Genes (4)
	Ecol\lacZ H Pi3K92E Scer\GAL4
Insertions (3)
	P{GawB}elav^C155 P{UAS-Dp110.W}II P{UAS-Dp110.W}III
Natural transposons (1)
	P-element