Reference Report

Reference
Citation	Joiner, W.J., Crocker, A., White, B.H., Sehgal, A. (2006). Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441(7094): 757--760. (Export to RIS)
FlyBase ID	FBrf0192316
Publication Type	Research paper
PubMed ID	16760980
PubMed Abstract	Sleep is one of the few major whole-organ phenomena for which no function and no underlying mechanism have been conclusively demonstrated. Sleep could result from global changes in the brain during wakefulness or it could be regulated by specific loci that recruit the rest of the brain into the electrical and metabolic states characteristic of sleep. Here we address this issue by exploiting the genetic tractability of the fruitfly, Drosophila melanogaster, which exhibits the hallmarks of vertebrate sleep. We show that large changes in sleep are achieved by spatial and temporal enhancement of cyclic-AMP-dependent protein kinase (PKA) activity specifically in the adult mushroom bodies of Drosophila. Other manipulations of the mushroom bodies, such as electrical silencing, increasing excitation or ablation, also alter sleep. These results link sleep regulation to an anatomical locus known to be involved in learning and memory.
DOI	10.1038/nature04811
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (28)
	Avic\GFP^Scer\UAS.cUa Bhal\NaChBac^{Scer\UAS.T:Avic\GFP-EGFP} Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Pkaca^mC.Scer\UAS Scer\GAL4^17d Scer\GAL4^30Y Scer\GAL4^85b Scer\GAL4^103Y Scer\GAL4^104Y Scer\GAL4^129Y Scer\GAL4^238Y Scer\GAL4^Aph-4-c232 Scer\GAL4^Aph-4-c507 Scer\GAL4^c309 Scer\GAL4^c492b Scer\GAL4^c739 Scer\GAL4^c747 Scer\GAL4^{elav.Switch.PO} Scer\GAL4^GMR.PF Scer\GAL4^H24 Scer\GAL4^{Mef2.247.Switch} Scer\GAL4^MJ63 Scer\GAL4^MJ286 Scer\GAL4^Mz1366 Scer\GAL4^P2.4.Pdf Scer\GAL4^per.PK Scer\GAL4^Tab2-201Y Sh^{EKO.Scer\UAS.T:Avic\GFP-GL}
Constructs (10)
	P{elav-Switch.O} P{GAL4-ninaE.GMR} P{GAL4-per.BS} P{MB-Switch} P{Pdf-GAL4.P2.4} P{UAS-EKO⁺} P{UAS-GFP.U} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-NaChBac-EGFP} P{UAS-PKA.mC}
Genes (6)
	Avic\GFP Bhal\NaChBac Hsap\KCNJ2 Mmus\Pkaca Scer\GAL4 Sh
Insertions (18)
	P{GAL4}17d P{GAL4}85b P{GAL4}H24 P{GAL4}Mz1366 P{GawB}30Y P{GawB}103Y P{GawB}104y P{GawB}129Y P{GawB}238Y P{GawB}Aph-4^c232 P{GawB}Aph-4^c507 P{GawB}c309 P{GawB}c492b P{GawB}c747 P{GawB}Hr39^c739 P{GawB}MJ63 P{GawB}MJ286 P{GawB}Tab2^201Y