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Reference Report
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| Citation | Lattemann, M., Zierau, A., Schulte, C., Seidl, S., Kuhlmann, B., Hummel, T. (2007). Semaphorin-1a controls receptor neuron-specific axonal convergence in the primary olfactory center of Drosophila. Neuron 53(2): 169--184. (Export to RIS) | ||
| FlyBase ID | FBrf0192333 | ||
| Publication Type | Research paper | ||
| PubMed ID | 17224401 | ||
| PubMed Abstract | In the olfactory system of Drosophila, 50 functional classes of sensory receptor neurons (ORNs) project in a highly organized fashion into the CNS, where they sort out from one another and converge into distinct synaptic glomeruli. We identified the transmembrane molecule Semaphorin-1a (Sema-1a) as an essential component to ensure glomerulus-specific axon segregation. Removal of sema-1a in ORNs does not affect the pathfinding toward their target area but disrupts local axonal convergence into a single glomerulus, resulting in two distinct targeting phenotypes: axons either intermingle with adjacent ORN classes or segregate according to their odorant receptor identity into ectopic sites. Differential Sema-1a expression can be detected among neighboring glomeruli, and mosaic analyses show that sema-1a functions nonautonomously in ORN axon sorting. These findings provide insights into the mechanism by which afferent interactions lead to synaptic specificity in the olfactory system. | ||
| DOI | 10.1016/j.neuron.2006.12.024 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Neuron | ||
| Title | Neuron | ||
| Publication Year | 1988- | ||
| ISBN/ISSN | 0896-6273 | ||
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Data from Reference
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| Genes (24)
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