Open Close
Reference
Citation
Pal Bhadra, M., Bhadra, U., Birchler, J.A. (2006). Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.  Genetics 174(3): 1151--1159.
FlyBase ID
FBrf0192394
Publication Type
Research paper
Abstract

A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of localization of the male-specific lethal (MSL) complex to the X chromosome, which causes changes in gene expression. Introduction of a Sxl mutation into this hybrid genotype will allow expression of the MSL complex but there is no sequestration to the X chromosome. Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos.

PubMed ID
PubMed Central ID
PMC1667077 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
  • FBrf0195932
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Genetics
Title
Genetics
Publication Year
1916-
ISBN/ISSN
0016-6731
Data From Reference