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Citation
Srahna, M., Leyssen, M., Choi, C.M., Fradkin, L.G., Noordermeer, J.N., Hassan, B.A. (2006). A signaling network for patterning of neuronal connectivity in the Drosophila brain.  PLoS Biol. 4(11): e348.
FlyBase ID
FBrf0192599
Publication Type
Research paper
Abstract

The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity. The Rac1 GTPase integrates a Wnt-Frizzled-Disheveled axon-stabilizing signal and a Branchless (FGF)-Breathless (FGF receptor) axon-retracting signal to modulate JNK activity. JNK activity is necessary and sufficient for axon extension, whereas the antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise wiring pattern.

PubMed ID
PubMed Central ID
PMC1592317 (PMC) (EuropePMC)
Related Publication(s)
Note

Signals that tell fly neurons to extend or retract.
Chanut, 2006, PLoS Biol. 4(11): e391 [FBrf0200120]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Biol.
    Title
    PLoS Biology
    Publication Year
    2003-
    ISBN/ISSN
    1545-7885 1544-9173
    Data From Reference