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Citation
Bray, S.J. (2006). Notch signalling: a simple pathway becomes complex.  Nat. Rev. Mol. Cell Biol. 7(9): 678--689.
FlyBase ID
FBrf0192604
Publication Type
Review
Abstract

A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Mol. Cell Biol.
    Title
    Nature Reviews. Molecular Cell Biology
    Publication Year
    2000-
    ISBN/ISSN
    1471-0072
    Data From Reference
    Gene Groups (1)