Reference Report

Reference
Citation	Bazigou, E., Apitz, H., Johansson, J., Loren, C.E., Hirst, E.M.A., Chen, P.L., Palmer, R.H., Salecker, I. (2007). Anterograde jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. Cell 128(5): 961--975. (Export to RIS)
FlyBase ID	FBrf0192674
Publication Type	Research paper
PubMed ID	17350579
PubMed Abstract	Anaplastic lymphoma kinase (Alk) has been proposed to regulate neuronal development based on its expression pattern in vertebrates and invertebrates; however, its function in vivo is unknown. We demonstrate that Alk and its ligand Jelly belly (Jeb) play a central role as an anterograde signaling pathway mediating neuronal circuit assembly in the Drosophila visual system. Alk is expressed and required in target neurons in the optic lobe, whereas Jeb is primarily generated by photoreceptor axons and functions in the eye to control target selection of R1-R6 axons in the lamina and R8 axons in the medulla. Impaired Jeb/Alk function affects layer-specific expression of three cell-adhesion molecules, Dumbfounded/Kirre, Roughest/IrreC, and Flamingo, in the medulla. Moreover, loss of flamingo in target neurons causes some R8-axon targeting errors observed in Jeb and Alk mosaic animals. Together, these findings suggest that Jeb/Alk signaling helps R-cell axons to shape their environment for target recognition.
DOI	10.1016/j.cell.2007.02.024
Related Publication(s)
Supplementary material	Supplemental Data. Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0199314]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (23)
	Alk¹ Alk⁸ Alk⁹ Alk^{EC.Scer\UAS.T:Hsap\MYC} Avic\GFP^Ubi-p63E.PD Btau\MAPT^{ato.hs.T:Hsap\MYC} Disc\RFP^{Scer\UAS.T:Myr-Src64B} Ecol\lacZ^{ninaE.-833+67} Ecol\lacZ^PD.Rh6 Ecol\lacZ^Rh4.PD jeb^Scer\UAS.cVa jeb^SH0422 Scer\FLP1^ey.3.5.hs Scer\FLP1^Scer\UAS.cDa Scer\GAL4^Act5C.PI Scer\GAL4^GMR.PF Scer\GAL4^kirre-rP298 Scer\GAL4^lama-A8 Scer\GAL4^twi.PG Scer\GAL80^ey.3.5 stan^{dsRNA.extra.Scer\UAS} stan^{dsRNA.intra.Scer\UAS} stan^E59
Constructs (16)
	P{Act5C-GAL4} P{ato-tau-myc} P{ey-FLP.3.5} P{ey-GAL80.3.5} P{GAL4-ninaE.GMR} P{GAL4-twi.G} P{Rh1(-833/+67)-β-gal} P{Rh4-lacZ.PD} P{Rh6-lacZ.PD} P{UAS-Alk.EC.MYC} P{UAS-FLP1.D} P{UAS-fmi.dsRNA.extra} P{UAS-fmi.dsRNA.intra} P{UAS-jeb.V} P{UAS-myr-mRFP} P{Ubi-GFP.D}
Genes (17)
	Alk Avic\GFP Btau\MAPT chp Disc\RFP Ecol\lacZ Fas3 jeb kirre repo Rh4 Rh6 rst Scer\FLP1 Scer\GAL4 Scer\GAL80 stan
Insertions (2)
	P{GAL4}rP298 P{GawB}A8C
Natural transposons (1)
	P-element