Reference Report

Reference
Citation	Jung, A.C., Ribeiro, C., Michaut, L., Certa, U., Affolter, M. (2006). Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Curr. Biol. 16(12): 1224--1231. (Export to RIS)
FlyBase ID	FBrf0192782
Publication Type	Research paper
PubMed ID	16782014
PubMed Abstract	The development of the complex network of epithelial tubes that ultimately forms the Drosophila tracheal system relies on cell migration, cell shape changes, cell rearrangements, cell differentiation, and branch fusion . Most of these events are controlled by a combination of distinct transcription factors and cell-cell signaling molecules, but few proteins that do not fall within these two functional classes have been associated with tracheal development. We show that the MAGUK protein Polychaetoid (Pyd/ZO-1), the Drosophila homolog of the junctional protein ZO-1 , plays a dual role in the formation of tracheal tubes. pyd/ZO-1 mutant embryos display branch fusion defects due to the lack of reliable determination of the fusion cell fate. In addition, pyd/ZO-1 mutant embryos show impaired cell intercalation in thin tracheal branches. Pyd/ZO-1 localizes to the adherens junctions (AJs) in tracheal cells and might thus play a direct role in the regulation of the dynamic state of the AJ during epithelial remodeling. Our study suggests that MAGUK proteins might play important roles during AJ remodeling in epithelial morphogenesis.
DOI	10.1016/j.cub.2006.04.048
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(3R)p-XT103
Alleles (15)
	Avic\GFP^Scer\UAS.cUa pyd^BG02748 pyd^C5 pyd^EY04259 pyd^KG00264 pyd^KG02008 pyd^Scer\UAS.cJa pyd^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^btl.PS Scer\GAL4^prd.RG1 shg^{Scer\UAS.T:Avic\GFP-rs} T:Avic\GFP^EGFP trh³ w^+mC α-Cat^{Scer\UAS.T:Avic\GFP-sg}
Constructs (9)
	P{GAL4-btl.S} P{GAL4-prd.F} P{GT1} P{SUPor-P} P{UAS-GFP.U} P{UAS-pyd.EGFP} P{UAS-pyd.J} P{UAS-shg.DEFL} P{UAS-α-Cat.T:GFP.sg}
Genes (9)
	Avic\GFP bs esg pyd Scer\GAL4 shg trh w α-Cat
Insertions (4)
	P{EPgy2}pyd^EY04259 P{GT1}pyd^BG02748 P{SUPor-P}pyd^KG00264 P{SUPor-P}pyd^KG02008
Natural transposons (1)
	P-element