Reference Report

Reference
Citation	Rossi, F., Moschetti, R., Caizzi, R., Corradini, N., Dimitri, P. (2007). Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. Genetics 175(2): 595--607. (Export to RIS)
FlyBase ID	FBrf0192814
Publication Type	Research paper
PubMed ID	17110485
PubMed Abstract	In the past decade, genome-sequencing projects have yielded a great amount of information on DNA sequences in several organisms. The release of the Drosophila melanogaster heterochromatin sequence by the Drosophila Heterochromatin Genome Project (DHGP) has greatly facilitated studies of mapping, molecular organization, and function of genes located in pericentromeric heterochromatin. Surprisingly, genome annotation has predicted at least 450 heterochromatic gene models, a figure 10-fold above that defined by genetic analysis. To gain further insight into the locations and functions of D. melanogaster heterochromatic genes and genome organization, we have FISH mapped 41 gene models relative to the stained bands of mitotic chromosomes and the proximal divisions of polytene chromosomes. These genes are contained in eight large scaffolds, which together account for approximately 1.4 Mb of heterochromatic DNA sequence. Moreover, developmental Northern analysis showed that the expression of 15 heterochromatic gene models tested is similar to that of the vital heterochromatic gene Nipped-A, in that it is not limited to specific stages, but is present throughout all development, despite its location in a supposedly "silent" region of the genome. This result is consistent with the idea that genes resident in heterochromatin can encode essential functions.
DOI	10.1534/genetics.106.065441
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Genes (94)
	Atf6 CG3107 CG10395 CG10396 CG10417 CG10465 CG11665 CG12547 CG12552 CG12567 CG14464 CG17082 CG17429 CG17478 CG17486 CG17490 CG17493 CG17494 CG17508 CG17514 CG17528 CG17683 CG17691 CG17715 CG30438 CG30440 CG30441 CG40005 CG40006 CG40040 CG40042 CG40081 CG40085 CG40103 CG40127 CG40128 CG40130 CG40131 CG40133 CG40163 CG40190 CG40191 CG40192 CG40211 CG40239 CG40241 CG40244 CG40290 CG40388 CG40390 CG40439 CG40498 CG41063 CG41065 CG41066 CG41098 CG41099 CG41101 CG41117 CG41118 CG41120 CG41121 CG41520 Cht3 CR14578 CR40068 CR40282 cta d4 eIF-4B Fis1 Gpb5 Gprk1 gus Haspin IntS3 Ir41a laccase2 lt Nipped-A Nipped-B p120ctn rl RpL5 RpL38 Spf45 Stlk sxc TpnC4 TpnC41C tRNA:CR30260 tRNA:CR30505 uex Yeti
Insertions (2)
	P{EPgy2}IntS3^EY09264 P{Fab7-w#un1}19.74.3
Natural transposons (1)
	gypsy12