|Citation||Stapleton, M., Carlson, J.W., Celniker, S.E. (2006). RNA editing in Drosophila melanogaster: New targets and functional consequences. RNA 12(11): 1922--1932. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Adenosine deaminases that act on RNA [adenosine deaminase, RNA specific (ADAR)] catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts. These re-coding events affect coding potential, splice sites, and stability of mature mRNAs. ADAR is an essential gene, and studies in mouse, Caenorhabditis elegans, and Drosophila suggest that its primary function is to modify adult behavior by altering signaling components in the nervous system. By comparing the sequence of isogenic cDNAs to genomic DNA, we have identified and experimentally verified 27 new targets of Drosophila ADAR. Our analyses led us to identify new classes of genes whose transcripts are targets of ADAR, including components of the actin cytoskeleton and genes involved in ion homeostasis and signal transduction. Our results indicate that editing in Drosophila increases the diversity of the proteome, and does so in a manner that has direct functional consequences on protein function.|
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|Language of Publication||English|
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|Also Published As|
|Title||RNA (New York, N.Y.)|
|Data from Reference|