Reference Report

Reference
Citation	Hutterer, A., Berdnik, D., Wirtz-Peitz, F., Zigman, M., Schleiffer, A., Knoblich, J.A. (2006). Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev. Cell 11(2): 147--157. (Export to RIS)
FlyBase ID	FBrf0192833
Publication Type	Research paper
PubMed ID	16890155
PubMed Abstract	The protein kinase Aurora-A is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis. Here, we describe the identification of Bora, a conserved protein that is required for the activation of Aurora-A at the onset of mitosis. In the Drosophila peripheral nervous system, bora mutants have defects during asymmetric cell division identical to those observed in aurora-A. Furthermore, overexpression of bora can rescue defects caused by mutations in aurora-A. Bora is conserved in vertebrates, and both Drosophila and human Bora can bind to Aurora-A and activate the kinase in vitro. In interphase cells, Bora is a nuclear protein, but upon entry into mitosis, Bora is excluded from the nucleus and translocates into the cytoplasm in a Cdc2-dependent manner. We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A.
DOI	10.1016/j.devcel.2006.06.002
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(3L)Cat
Alleles (11)
	aur³⁷ bora¹⁵ bora¹⁸ bora^{Scer\UAS.T:Avic\GFP-S65T} bora^unspecified His2A^{Scer\UAS.T:Disc\RFP} Scer\GAL4^neur-P72 Scer\GAL4^sca-109-68 stg^unspecified T:Avic\GFP^S65T w^+mC
Constructs (2)
	P{UAS-bora-GFP} P{UAS-His-RFP}
Genes (17)
	ase aur bora cnn ct Gαi His2A numb pon pros raps Scer\GAL4 stg Su(H) tacc w γTub23C
Insertions (2)
	P{GAL4}neur^P72 P{GawB}sca^109-68
Natural transposons (1)
	P-element