Reference Report

Reference
Citation	Guan, J., Li, H., Rogulja, A., Axelrod, J.D., Cadigan, K.M. (2007). The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Dev. Biol. 303(1): 16--28. (Export to RIS)
FlyBase ID	FBrf0192905
Publication Type	Research paper
PubMed ID	17134692
PubMed Abstract	The proper number of cells in developing tissues is achieved by coordinating cell division with apoptosis. In Drosophila, the adult wing is derived from wing imaginal discs, which undergo a period of growth and proliferation during larval stages without much programmed cell death. In this report, we demonstrate that the Drosophila casein kinase Iepsilon/delta, known as Discs overgrown (Dco), is required for maintaining this low level of apoptosis. Expression of dco can suppress the apoptotic activity of Head involution defective (Hid) in the developing eye. Loss of dco in the wing disc results in a dramatic reduction in expression of the caspase inhibitor DIAP1 and a concomitant activation of caspases. The regulation of DIAP1 by Dco occurs by a post-transcriptional mechanism that is independent of hid. Mutant clones of dco are considerably smaller than controls even when apoptosis is inhibited, suggesting that Dco promotes cell division/growth in addition to its role in cell survival. The dco phenotype cannot be explained by defects Wingless (Wg) signaling. We propose that Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression.
DOI	10.1016/j.ydbio.2006.10.028
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (2)
	Df(3L)H99 Df(3L)X14
Alleles (22)
	BacA\p35^Scer\UAS.cHa dco^{D132N.Scer\UAS} dco^{dsRNA.Scer\UAS} dco^{K38R.Scer\UAS} dco^le88 dco^S091510 dco^S139602 dco^{Scer\FRT.K38R.Scer\UAS} dco^Scer\UAS.cKa dco^Scer\UAS.cSa dco^Scer\UAS.cSb Ecol\lacZ^Scer\UAS.cBa grim^GMR.PC rpr^GMR.PW Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^ptc-559.1 th^6B th^j5C8 W⁰⁵⁰¹⁴ W^Ala5.GMR W^GMR.PG
Constructs (14)
	P{GAL4-ninaE.GMR} P{GMR-grim} P{GMR-hid.Ala5} P{GMR-hid} P{GMR-rpr.W} P{Scer\UAS(FRT.polyA)dco.K38R} P{UAS(-FRT)dco.K38R} P{UAS-dco.D132N} P{UAS-dco.dsRNA} P{UAS-dco.K} P{UAS-dco.S} P{UAS-dco.Sb} P{UAS-lacZ.B} P{UAS-p35.H}
Genes (13)
	BacA\p35 dco Dll Ecol\lacZ grim Ice rpr salm Scer\GAL4 sens th W wg
Insertions (8)
	P{en2.4-GAL4}e16E P{GawB}ptc^559.1 P{GMR-grim}2 P{GMR-grim}3 P{GMR-hid}1M P{GMR-hid}10 P{GMR-rpr.W}2 P{GMR-rpr.W}5
Natural transposons (1)
	P-element