Reference Report

Reference
Citation	Han, J., Gong, P., Reddig, K., Mitra, M., Guo, P., Li, H.S. (2006). The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor. Cell 127(4): 847--858. (Export to RIS)
FlyBase ID	FBrf0192912
Publication Type	Research paper
PubMed ID	17110341
PubMed Abstract	Control of membrane-receptor activity is required not only for the accuracy of sensory responses, but also to protect cells from excitotoxicity. Here we report the isolation of two noncomplementary fly mutants with slow termination of photoresponses. Genetic and electrophysiological analyses of the mutants revealed a defect in the deactivation of rhodopsin, a visual G protein-coupled receptor (GPCR). The mutant gene was identified as the calmodulin-binding transcription activator (dCAMTA). The known rhodopsin regulator Arr2 does not mediate this visual function of dCAMTA. A genome-wide screen identified five dCAMTA target genes. Of these, overexpression of the F box gene dFbxl4 rescued the mutant phenotypes. We further showed that dCAMTA is stimulated in vivo through interaction with the Ca(2+) sensor calmodulin. Our data suggest that calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2+)-stimulating GPCRs, which could prevent cell damage due to extra Ca(2+) influx.
DOI	10.1016/j.cell.2006.09.030
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(2R)w45-19g Df(2R)w73-1
Alleles (22)
	Arr2⁵ Camta^hs.PH Camta^m2Q1.hs Camta^m2Q1.trp Camta^m3Q1.hs Camta^m3Q1.trp Camta^mlQ1.hs Camta^mlQ1.trp Camta^tes-1 Camta^tes-2 Camta^trp.PH Cpr72Ec^hs.PH Fbxl4^hs.PH Fbxl4^trp.PH Gαq¹ ltl^hs.PH ninaE⁷ ninaE⁸ norpA^unspecified rdgA^unspecified so^unspecified trp^Δ1272
Constructs (12)
	P{hs-Camta.H} P{hs-Camta.m2Q1} P{hs-Camta.m3Q1} P{hs-Camta.mlQ1} P{hs-CG4784.H} P{hs-CG32372.H} P{hs-Fbxl4.H} P{trp-Camta.H} P{trp-Camta.m2Q1} P{trp-Camta.m3Q1} P{trp-Camta.mlQ1} P{trp-Fbxl4.H}
Genes (20)
	Arr2 Camta ced-6 CG7227 CG32532 Cpr72Ec Fbxl4 Gαq inaC inaD ltl ninaC ninaE norpA Pdk Ppyr\LUC rdgA rdgC so trp
Insertions (1)
	P{EPgy2}EY02897
Natural transposons (1)
	P-element