Reference Report

Reference
Citation	Takaesu, N.T., Hyman-Walsh, C., Ye, Y., Wisotzkey, R.G., Stinchfield, M.J., O'Connor, M.B., Wotton, D., Newfeld, S.J. (2006). dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics 174(3): 1299--1313. (Export to RIS)
FlyBase ID	FBrf0193040
Publication Type	Research paper
PubMed ID	16951053
PubMed Abstract	A screen for modifiers of Dpp adult phenotypes led to the identification of the Drosophila homolog of the Sno oncogene (dSno). The dSno locus is large, transcriptionally complex and contains a recent retrotransposon insertion that may be essential for dSno function, an intriguing possibility from the perspective of developmental evolution. dSno is highly transcribed in the embryonic central nervous system and transcripts are most abundant in third instar larvae. dSno mutant larvae have proliferation defects in the optic lobe of the brain very similar to those seen in baboon (Activin type I receptor) and dSmad2 mutants. This suggests that dSno is a mediator of Baboon signaling. dSno binds to Medea and Medea/dSno complexes have enhanced affinity for dSmad2. Alternatively, Medea/dSno complexes have reduced affinity for Mad such that, in the presence of dSno, Dpp signaling is antagonized. We propose that dSno functions as a switch in optic lobe development, shunting Medea from the Dpp pathway to the Activin pathway to ensure proper proliferation. Pathway switching in target cells is a previously unreported mechanism for regulating TGFbeta signaling and a novel function for Sno/Ski family proteins.
DOI	10.1534/genetics.106.064956
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(2L)BSC41 In(2L)DTD46.3
Alleles (27)
	babo³² babo⁵² CG7231^DG01605 CG7231^EY11884 CG7231^KG04307 Mad^1.Scer\UAS Mad¹ Mad^Scer\UAS.cNa Med^Scer\UAS.cSa Scer\GAL4^32B Scer\GAL4^A9 Scer\GAL4^hs.PB Smox^MB388 Smox^Scer\UAS.cZa Snoo^BSC41 Snoo^EX4B Snoo^EX8B Snoo^EX9B Snoo^EX10B Snoo^EX17B Snoo^EX34A Snoo^EX71B Snoo^EX95A Snoo^Scer\UAS.cTa Snoo^SH1402 tkv^{Q199D.Scer\UAS.T:Ivir\HA1} w^+mC
Constructs (7)
	P{GAL4-Hsp70.PB} P{UAS-dSmad2.Z} P{UAS-Mad.1} P{UAS-Mad.N} P{UAS-Med.S} P{UAS-Snoo.T} P{UAS-tkv^Q199D}
Genes (19)
	babo bs CG7231 chp Csp dac dpp EcR elav fuss His3 Mad Med robo Scer\GAL4 Smox Snoo tkv w
Insertions (7)
	297{}323 P{EPgy2}CG7231^EY11884 P{GAL4}A9 P{GawB}32B P{lacW}Snoo^SH1402 P{SUPor-P}CG7231^KG04307 P{wHy}Snoo^DG01605
Natural transposons (1)
	P-element