Reference Report

Reference
Citation	Jaekel, R., Klein, T. (2006). The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev. Cell 11(5): 655--669. (Export to RIS)
FlyBase ID	FBrf0193163
Publication Type	Research paper
PubMed ID	17084358
PubMed Abstract	Notch signaling is involved in many developmental and pathological processes, and its activity must be precisely controlled in order to prevent aberrant development and disease. We have previously shown that the tumor suppressor gene lethal (2) giant discs (lgd) is required to prevent ectopic activation of Notch in developmental processes in Drosophila. Here we show that lgd is required in all imaginal disc cells to suppress the activity of the Notch pathway. lgd encodes a member of a poorly characterized protein family present in all animals, which includes a member that is involved in an inheritable form of mental retardation in humans. Our analysis reveals that Lgd is required for endosomal trafficking of Notch and other proteins. In the absence of Lgd, Notch is activated in a ligand-independent manner in probably all imaginal disc cells in an endosomal compartment downstream of the block in hrs mutants.
DOI	10.1016/j.devcel.2006.09.019
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (2)
	Df(2L)FCK-20 Df(3L)mib1²
Alleles (36)
	Avic\GFP^{Scer\UAS.T:Hsap\MYC,T:Mmus\2xFYVE} Avic\GFP^{Scer\UAS.T:Ocun\LPH-ss,T:Hsap\LFA3-GPI} Avic\GFP^Su(H).ASE BacA\p35^Scer\UAS.cHa Dl^RevF10 Ecol\lacZ^{Ddc.be2.E(spl).m8} Ecol\lacZ^wg-en11 Hrs^D28 krz^{Scer\UAS.T:Ivir\HA1} l(2)gd1¹ l(2)gd1⁴ l(2)gd1^d7 l(2)gd1^d10 l(2)gd1^rsk73a l(2)gd1^rsk83a l(2)gd1^{Scer\UAS.cJa.T:Ivir\HA1} l(2)gd1^Scer\UAS.cJa l(2)gd1^SH0495 lqf¹²²⁷ lqf^L71 Mmus\Cc2d1a^Scer\UAS.cJa Mmus\Cc2d1b^Scer\UAS.cJa N^Scer\UAS.cBb Nedd4^C974FS Nedd4^GS13178 Psn^C1 Rab5^{Scer\UAS.T:Avic\GFP-EGFP} Rab7^{Scer\UAS.T:Avic\GFP} Rab11^T:Avic\GFP Scer\GAL4^da.G32 Scer\GAL4^hh-Gal4 Scer\GAL4^ptc-559.1 Scer\GAL4^sd-SG29.1 Scer\GAL4^tub.PU Ser^RX82 Su(H)⁸
Constructs (16)
	P{?lacW} P{Ddc.E(spl)-lacZ.Gbe.m8} P{GAL4-da.G32} P{Rab11.T:GFP.D} P{Su(H)-GFP.ASE} P{tub-GAL4.U} P{UAS-Cc2d1b.J} P{UAS-GFP.gpi} P{UAS-GFP-myc-2xFYVE} P{UAS-GFP-Rab5} P{UAS-krz.HA} P{UAS-l(2)gd1.J} P{UAS-lgd.HA.J} P{UAS-N.Bb} P{UAS-p35.H} P{UAS-Rab7.GFP}
Genes (34)
	aPKC arm Avic\GFP BacA\p35 crb ct Dl dlg1 dor Ecol\lacZ Hrs krz l(2)gd1 lqf lva mib1 Mmus\Cc2d1a Mmus\Cc2d1b N Nedd4 Psn ptc Rab5 Rab7 Rab11 Scer\GAL4 sens Ser spin Su(H) Syx7 T:Ivir\HA1 T:Ivir\haemagglutinin wg
Insertions (7)
	P{?lacW}l(2)gd1^rsk73a P{?lacW}l(2)gd1^rsk83a P{en1}wg^en11 P{GAL4}hh^Gal4 P{GawB}ptc^559.1 P{GawB}sd^SG29.1 P{GSV6}Nedd4^GS13178