Reference Report

Reference
Citation	Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., Irvine, K.D. (2006). Delineation of a Fat tumor suppressor pathway. Nat. Genet. 38(10): 1142--1150. (Export to RIS)
FlyBase ID	FBrf0193283
Publication Type	Research paper
PubMed ID	16980976
PubMed Abstract	Recent studies in Drosophila melanogaster of the protocadherins Dachsous and Fat suggest that they act as ligand and receptor, respectively, for an intercellular signaling pathway that influences tissue polarity, growth and gene expression, but the basis for signaling downstream of Fat has remained unclear. Here, we characterize functional relationships among D. melanogaster tumor suppressors and identify the kinases Discs overgrown and Warts as components of a Fat signaling pathway. fat, discs overgrown and warts regulate a common set of downstream genes in multiple tissues. Genetic experiments position the action of discs overgrown upstream of the Fat pathway component dachs, whereas warts acts downstream of dachs. Warts protein coprecipitates with Dachs, and Warts protein levels are influenced by fat, dachs and discs overgrown in vivo, consistent with its placement as a downstream component of the pathway. The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate Warts activity independently. Our results functionally link what had been four disparate groups of D. melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals.
DOI	10.1038/ng1887
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Genet.
Title	Nature Genetics
Publication Year	1992-
ISBN/ISSN	1061-4036 1546-1718
Data from Reference
Alleles (28)
	BacA\p35^Scer\UAS.cHa ban^GS d¹ d^GC13 dco³ ds^GS.D Ecol\lacZ^ex-697 Ecol\lacZ^fj-p1 Ecol\lacZ^th-j5C8 ex^e1 ex^Scer\UAS.cBa fj^Scer\UAS.cZa ft⁸ ft^G-rv ft^Scer\UAS.cMa hpo^42-47 mats^e235 Mer⁴ Mer^Ubi-p63E.PM sav³ sav^{Scer\UAS.T:Ivir\HA1} Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^tub.PU wts^P1 wts^P2 wts^{Scer\UAS.T:Hsap\MYC} wts^x1 yki^Scer\UAS.cHa
Constructs (11)
	P{AyGAL4} P{ex} P{GSV1} P{tub-GAL4.U} P{UAS-fj} P{UAS-ft.M} P{UAS-p35.H} P{UAS-sav.HA} P{UAS-wts.MYC} P{UAS-yki} P{Ubi-p63E-Mer.M}
Genes (23)
	BacA\p35 ban CycE d dco ds Ecol\lacZ en ex fj ft hpo mats Mer nub sav Scer\GAL4 Ser th vg wg wts yki
Insertions (5)
	P{GSV1}ban^GS P{GSV1}ds^GS.D P{lacW}ex⁶⁹⁷ P{lacW}fj^p1 P{lacW}th^j5C8