Reference Report

Reference
Citation	Li, Y., Wang, F., Lee, J.A., Gao, F.B. (2006). MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev. 20(20): 2793--2805. (Export to RIS)
FlyBase ID	FBrf0193418
Publication Type	Research paper
PubMed ID	17015424
PubMed Abstract	MicroRNAs (miRNAs) have been implicated in regulating various aspects of animal development, but their functions in neurogenesis are largely unknown. Here we report that loss of miR-9a function in the Drosophila peripheral nervous system leads to ectopic production of sensory organ precursors (SOPs), whereas overexpression of miR-9a results in a severe loss of SOPs. We further demonstrate a strong genetic interaction between miR-9a and senseless (sens) in controlling the formation of SOPs in the adult wing imaginal disc. Moreover, miR-9a suppresses Sens expression through its 3' untranslated region. miR-9a is expressed in epithelial cells, including those adjacent to SOPs within proneural clusters, suggesting that miR-9a normally inhibits neuronal fate in non-SOP cells by down-regulating Sens expression. These results indicate that miR-9a ensures the generation of the precise number of neuronal precursor cells during development.
DOI	10.1101/gad.1466306
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (16)
	mir-9a^E39 mir-9a^E44 mir-9a^E45 mir-9a^J22 mir-9a^J34 mir-9a^mut.Scer\UAS mir-9a^Scer\UAS.cLa mir-9a^{w.Scer\SceI.RS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4²²¹ Scer\GAL4^ap-md544 Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^vg.PU sens^E58 sens^Scer\UAS.cNa w^+mC
Constructs (6)
	P{FRT(w⁺.mir-9a^{w.Scer\SceI.RS})} P{UAS-mCD8::GFP.L} P{UAS-mir-9a.L} P{UAS-mir-9a.mut} P{UAS-sens.N} P{vg-GAL4.U}
Genes (10)
	CG9300 ct Dpse\mir-9a elav mir-9a Mmus\Cd8a Scer\GAL4 sens Shal w
Insertions (4)
	P{GawB}ap^md544 P{GawB}neur^GAL4-A101 P{UAS-mir-9a.L}3 P{UAS-mir-9a.L}8
Natural transposons (1)
	P-element