Reference Report

Reference
Citation	Mao, Y., Rauskolb, C., Cho, E., Hu, W.L., Hayter, H., Minihan, G., Katz, F.N., Irvine, K.D. (2006). Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133(13): 2539--2551. (Export to RIS)
FlyBase ID	FBrf0193425
Publication Type	Research paper
PubMed ID	16735478
PubMed Abstract	The dachs gene was first identified almost a century ago based on its requirements for appendage growth, but has been relatively little studied. Here, we describe the phenotypes of strong dachs mutations, report the cloning of the dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings. dachs encodes an unconventional myosin that preferentially localizes to the membrane of imaginal disc cells. dachs mutations suppress the effects of fat mutations on gene expression, cell affinity and growth in imaginal discs. Dachs protein localization is influenced by Fat, Four-jointed and Dachsous, consistent with its genetic placement downstream of fat. However, dachs mutations have only mild tissue polarity phenotypes, and only partially suppress the tissue polarity defects of fat mutants. Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development.
DOI	10.1242/dev.02427
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Df(2L)ED623 Df(2L)N22-3 Df(2L)N22-5 Df(2L)N22-14 Df(2L)TE30Cb-1
Alleles (19)
	Avic\GFP^Scer\UAS.cUa ck¹³ d¹ d²¹⁰ d^GC2 d^GC13 d^Scer\UAS.cMa d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} ds^36D ds^GS.D ds^UAO71 Ecol\lacZ^fj-p1 fj^d1 fj^Scer\UAS.cZa ft⁸ ft^G-rv ft^Scer\UAS.cMa Scer\GAL4^Act5C.PI Scer\GAL4^tub.PU
Constructs (8)
	P{Act5C-GAL4} P{AyGAL4} P{tub-GAL4.U} P{UAS-d.M} P{UAS-d.V5} P{UAS-fj} P{UAS-ft.M} P{UAS-GFP.U}
Genes (15)
	Avic\GFP ck d ds Ecol\lacZ elav fj ft pros Scer\GAL4 Ser shg T:SV5\V5 T:Zzzz\His6 wg
Insertions (12)
	blood{}d¹ P{GSV1}ds^GS.D P{lacW}fj^p1 P{UAS-d.M}2A P{UAS-d.M}2B P{UAS-d.M}2D P{UAS-d.V5}8-3 P{UAS-d.V5}9-F P{UAS-d.V5}18-2 P{UAS-d.V5}18-4 P{UAS-d.V5}50-5 P{UAS-fj}6a.2
Natural transposons (2)
	blood P-element