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Citation
Xu, D., Wang, Y., Willecke, R., Chen, Z., Ding, T., Bergmann, A. (2006). The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.  Cell Death Differ. 13(10): 1697--1706.
FlyBase ID
FBrf0193497
Publication Type
Research paper
Abstract

Caspases are essential components of the apoptotic machinery in both vertebrates and invertebrates. Here, we report the isolation of a mutant allele of the Drosophila effector caspase drICE as a strong suppressor of hid- (head involution defective-) induced apoptosis. This mutant was used to determine the apoptotic role of drICE. Our data are consistent with an important function of drICE for developmental and irradiation-induced cell death. Epistatic analysis suggests that drICE acts genetically downstream of Drosophila inhibitor of apoptosis protein 1 (Diap1). However, although cell death is significantly reduced in drICE mutants in all assays, it is not completely blocked. A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1. Thus, these data demonstrate a barely appreciated complexity in the apoptotic pathway, and are consistent with current models about effector caspase regulation in both vertebrates and invertebrates.

PubMed ID
PubMed Central ID
PMC2519037 (PMC) (EuropePMC)
Associated Information
Comments
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Secondary IDs
  • FBrf0189953
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Cell Death Differ.
Title
Cell Death and Differentiation
Publication Year
1994-
ISBN/ISSN
1350-9047
Data From Reference
Aberrations (1)
Alleles (11)
Genes (12)
Insertions (1)
Transgenic Constructs (8)