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Reference Report
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| Citation | Didelot, G., Molinari, F., Tchenio, P., Comas, D., Milhiet, E., Munnich, A., Colleaux, L., Preat, T. (2006). Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila. Science 313(5788): 851--853. (Export to RIS) | ||
| FlyBase ID | FBrf0193536 | ||
| Publication Type | Research paper | ||
| PubMed ID | 16902143 | ||
| PubMed Abstract | Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM)-specific defect. After LTM conditioning of wild-type flies, teq expression transiently increased in the mushroom bodies. Moreover, specific inhibition of teq expression in adult mushroom bodies resulted in a reversible LTM defect. Hence, the Teq pathway is essential for information processing in Drosophila. | ||
| DOI | 10.1126/science.1127215 | ||
| Related Publication(s) | |||
| Research paper | Comment on "Tequila, a Neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Sonderegger and Patthy, 2007, Science 316(5832): 1698 [FBrf0200241] |
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| Supplementary material | [FBrf0198716] |
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| Note | Response to comment on "Tequila, a Neurotrypsin ortholog, regulates long-term memory formation in Drosophila". Preat et al., 2007, Science 316(5832): 1698 [FBrf0200282] |
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Other Information
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Science | ||
| Title | Science | ||
| Publication Year | 1895- | ||
| ISBN/ISSN | 0036-8075 | ||
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Data from Reference
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| Alleles (4)
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| Constructs (3)
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| Genes (4)
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