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Citation
Deng, X., Meller, V.H. (2006). Non-coding RNA in fly dosage compensation.  Trends Biochem. Sci. 31(9): 526--532.
FlyBase ID
FBrf0193541
Publication Type
Review
Abstract
Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.
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Secondary IDs
  • FBrf0198767
Language of Publication
English
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Publication Type
Compendium
Abbreviation
Trends Biochem. Sci.
Title
Trends in Biochemical Sciences
Publication Year
1976-
ISBN/ISSN
0167-7640 0968-0004
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