Reference Report

Reference
Citation	Otsuna, H., Ito, K. (2006). Systematic analysis of the visual projection neurons of Drosophila melanogaster. I. Lobula-specific pathways. J. Comp. Neurol. 497(6): 928--958. (Export to RIS)
FlyBase ID	FBrf0193607
Publication Type	Research paper
PubMed ID	16802334
PubMed Abstract	In insects, visual information is processed in the optic lobe and conveyed to the central brain. Although neural circuits within the optic lobe have been studied extensively, relatively little is known about the connection between the optic lobe and the central brain. To understand how visual information is read by the neurons of the central brain, and what kind of centrifugal neurons send the control signal from the central brain to the optic lobe, we performed a systematic analysis of the visual projection neurons that connect the optic lobe and the central brain of Drosophila melanogaster. By screening approximately 4,000 GAL4 enhancer-trap strains we identified 44 pathways. The overall morphology and the direction of information of each pathway were investigated by expressing cytoplasmic and presynapsis-targeted fluorescent reporters. A canonical nomenclature system was introduced to describe the area of projection in the central brain. As the first part of a series of articles, we here describe 14 visual projection neurons arising specifically from the lobula. Eight pathways form columnar arborization in the lobula, whereas the remaining six form tangential or tree-like arborization. Eleven are centripetal pathways, among which nine terminate in the ventrolateral protocerebrum. Terminals of each columnar pathway form glomerulus-like structures in different areas of the ventrolateral protocerebrum. The posterior lateral protocerebrum and the optic tubercle were each contributed by a single centripetal pathway. Another pathway connects the lobula on each side of the brain. Two centrifugal pathways convey signals from the posterior lateral protocerebrum to the lobula.
DOI	10.1002/cne.21015
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Comp. Neurol.
Title	Journal of Comparative Neurology
Publication Year	1911-
ISBN/ISSN	0021-9967
Data from Reference
Alleles (29)
	Avic\GFP^{S65T.Scer\UAS} Disc\RFP^{S197Y.Scer\UAS.P\T} Ecol\lacZ^Scer\UAS.cBa n-syb^{Scer\UAS.cEa.T:Avic\GFP} Scer\GAL4^ato.3.6 Scer\GAL4^ato-NP6558 Scer\GAL4^{CG17323-NP7067} Scer\GAL4^NP0681 Scer\GAL4^NP1035 Scer\GAL4^NP1047 Scer\GAL4^NP1195 Scer\GAL4^NP1320 Scer\GAL4^NP2331 Scer\GAL4^NP2450 Scer\GAL4^NP2620 Scer\GAL4^NP3045 Scer\GAL4^NP5006 Scer\GAL4^NP5039 Scer\GAL4^NP6099 Scer\GAL4^NP6250 Scer\GAL4^NP6502 Scer\GAL4^NP6563 Scer\GAL4^NP7121 Scer\GAL4^NP7226 Scer\GAL4^NP7233 Scer\GAL4^NP7281 Scer\GAL4^NP7302 Scer\GAL4^NP7365 Scer\GAL4^NP7476
Constructs (6)
	P{ato-GAL4.3.6} P{GawB} P{UAS-GFP.S65T} P{UAS-lacZ.B} P{UAS-n-syb-GFP.E} P{UASp-DsRed.S197Y}
Genes (44)
	ato Avic\GFP CG4363 CG8509 CG9153 CG9630 CG11671 CG13492 CG14460 CG15061 CG15233 CG15234 CG15445 CG17322 CG17323 CG17324 CG32450 CG34120 CG40262 CG40264 CG44774 Chc chinmo cmpy D1 Disc\RFP Ecol\lacZ His2A:CG31618 His3:CG31613 His4:CG31611 His-Ψ:CR31614 jing kni Myo61F n-syb Ptp4E pum Scer\GAL4 sd SNF4Aγ Snmp1 Ten-m unc upd3
Insertions (24)
	P{GawB}ato^NP6558 P{GawB}CG15445^NP7226 P{GawB}CG17323^NP7067 P{GawB}CG44774^NP5039 P{GawB}chinmo^NP2620 P{GawB}jing^NP1195 P{GawB}Myo61F^NP1320 P{GawB}NP0681 P{GawB}NP1047 P{GawB}NP2450 P{GawB}NP3045 P{GawB}NP5006 P{GawB}NP6099 P{GawB}NP6250 P{GawB}NP6502 P{GawB}NP7121 P{GawB}NP7233 P{GawB}NP7302 P{GawB}NP7365 P{GawB}pum^NP2331 P{GawB}sd^NP1035 P{GawB}SNF4Aγ^NP7476 P{GawB}Ten-m^NP6563 P{GawB}tlk^NP7281
Natural transposons (4)
	1360 jockey Quasimodo Rt1c
Transcripts (22)
	Scer\GAL4^ato-NP6558RA Scer\GAL4^{CG17323-NP7067}RA Scer\GAL4^NP0681RA Scer\GAL4^NP1047RA Scer\GAL4^NP1195RA Scer\GAL4^NP1320RA Scer\GAL4^NP2331RA Scer\GAL4^NP2450RA Scer\GAL4^NP2620RA Scer\GAL4^NP3045RA Scer\GAL4^NP5006RA Scer\GAL4^NP5039RA Scer\GAL4^NP6099RA Scer\GAL4^NP6250RA Scer\GAL4^NP6502RA Scer\GAL4^NP6563RA Scer\GAL4^NP7121RA Scer\GAL4^NP7226RA Scer\GAL4^NP7281RA Scer\GAL4^NP7302RA Scer\GAL4^NP7365RA Scer\GAL4^NP7476RA