Reference Report

Reference
Citation	Wehn, A., Campbell, G. (2006). Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression. Genetics 173(2): 849--861. (Export to RIS)
FlyBase ID	FBrf0193648
Publication Type	Research paper
PubMed ID	16624911
PubMed Abstract	In eukaryotes, the ability of DNA-binding proteins to act as transcriptional repressors often requires that they recruit accessory proteins, known as corepressors, which provide the activity responsible for silencing transcription. Several of these factors have been identified, including the Groucho (Gro) and Atrophin (Atro) proteins in Drosophila. Here we demonstrate strong genetic interactions between gro and Atro and also with mutations in a third gene, scribbler (sbb), which encodes a nuclear protein of unknown function. We show that mutations in Atro and Sbb have similar phenotypes, including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with Atro to provide repressive activity. Comparison of gro and Atro/sbb mutant phenotypes suggests that they do not function together, but instead that they may interact with the same transcription factors, including Engrailed and C15, to provide these proteins with maximal repressive activity.
DOI	10.1534/genetics.105.055012
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (3)
	Df(2R)en^E Df(2R)PC4 Df(3R)Espl22
Alleles (20)
	al¹³⁰ al^ice al^unspecified al^ush Avic\GFP^{hs.T:Hsap\MYC} Avic\GFP^{hs.T:Ivir\HA1} Avic\GFP^{S65T.Ubi-p63E.T:SV40\nls2} Ecol\lacZ^dpp-10638 Ecol\lacZ^tkv-04415 en^E gro^E48 gro^Eal13 gro^Eal37 Gug³⁵ Gug^Eal15 Gug^Eal73 Rnor\CD2^hs.PJ sbb⁶ sbb^Eal4 sbb^Eal17
Constructs (4)
	P{hs-flu-GFP} P{hsp70-CD2.J} P{hsp70-Myc-GFP} P{Ubi-GFP(S65T)nls}
Genes (14)
	al Avic\GFP B ci dpp Ecol\lacZ elav en gro Gug Rnor\CD2 run sbb tkv
Insertions (2)
	P{PZ}dpp¹⁰⁶³⁸ P{PZ}tkv⁰⁴⁴¹⁵