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Citation
Arbouzova, N.I., Zeidler, M.P. (2006). JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions.  Development 133(14): 2605--2616.
FlyBase ID
FBrf0193685
Publication Type
Review
Abstract

High levels of interspecies conservation characterise all signal transduction cascades and demonstrate the significance of these pathways over evolutionary time. Here, we review advances in the field of JAK/STAT signalling, focusing on recent developments in Drosophila. In particular, recent results from genetic and genome-wide RNAi screens, as well as studies into the developmental roles played by this pathway, highlight striking levels of physical and functional conservation in processes such as cellular proliferation, immune responses and stem cell maintenance. These insights underscore the value of model organisms for improving our understanding of this human disease-relevant pathway.

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Secondary IDs
  • FBrf0198646
Language of Publication
English
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Publication Type
Journal
Abbreviation
Development
Title
Development
Publication Year
1987-
ISBN/ISSN
0950-1991
Data From Reference
Alleles (4)
Genes (31)
Insertions (1)