Reference Report

Reference
Citation	Brun, S., Rincheval-Arnold, A., Colin, J., Risler, Y., Mignotte, B., Guenal, I. (2006). The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers. Cell Death Differ. 13(10): 1752--1762. (Export to RIS)
FlyBase ID	FBrf0193692
Publication Type	Research paper
PubMed ID	16456582
PubMed Abstract	We carried out gain-of-function mutagenesis screening and identified a mutant in which GAL4 induction led to both hyperplasia and apoptosis. The gene involved was identified as stonewall (stwl), a myb-related gene involved in germ cell proliferation and differentiation during oogenesis. As observed with dmyb, the ectopic expression of stwl(UY823) inhibited endoreplication in salivary glands. We also found that stwl(UY823) overexpression, like overexpression of the wild-type gene, activated G1/S transition and apoptosis. The apoptosis triggered by stwl(UY823) expression is correlated to induction of the proapoptotic gene reaper. Finally, the death of flies induced by ectopic stwl(UY823) expression is efficiently prevented in vivo by triggering cell death in stwl(UY823)-expressing cells. Our results suggest that stwl(UY823) kills flies by causing inappropriate cell cycle entry, and that triggering the death of these overproliferating cells or slowing their proliferation restores viability.
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Secondary IDs	FBrf0189944
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell Death Differ.
Title	Cell Death and Differentiation
Publication Year	1994-
ISBN/ISSN	1350-9047
Data from Reference
Aberrations (3)
	Df(3L)Brd6 Df(3L)fz-D21 Df(3L)fz-GS1a
Alleles (27)
	BacA\p35^Scer\UAS.cHa brat^UY1131 dap^Scer\UAS.cLa Dredd^Scer\UAS.cVa Ecol\lacZ^rpr.PN grim^Scer\UAS.cNa Hsap\BCL2^Scer\UAS.cGa Mmus\Bax^Scer\UAS.cGb Nc^{Scer\UAS.T:Avic\GFP-EGFP} p53^GUS.PB Rbf^Scer\UAS.cDa rpr^Scer\UAS.cZa Scer\GAL4^da.G32 Scer\GAL4^en.PU Scer\GAL4^fkh.PZ Scer\GAL4^GMR.PF Scer\GAL4^hs.PB Scer\GAL4^vg.PM skl^Scer\UAS.cSa stwl^+mCa stwl^GS3129 stwl^hs.PC stwl^j6C3 stwl^UY823 stwl^Δ95 th^Scer\UAS.cHa W^Scer\UAS.cZa
Constructs (23)
	P{en-GAL4.U} P{fkh-GAL4.Z} P{GAL4-da.G32} P{GAL4-Hsp70.PB} P{GAL4-ninaE.GMR} P{GAL4-vg.M} P{GUS-p53} P{hsp70-stwl} P{Mae-UAS.6.11} P{Rpr-11-lacZ} P{stwl.mini} P{UAS-bax.G} P{UAS-dap.L} P{UAS-DIAP1.H} P{UAS-Dredd.V} P{UAS-grim.N} P{UAS-hBcl-2.G} P{UAS-Nc.EGFP} P{UAS-p35.H} P{UAS-Rbf.D} P{UAS-rpr.Z} P{UAS-skl.S} P{UAS-W.Z}
Genes (17)
	BacA\p35 brat dap Dredd Ecol\lacZ grim Hsap\BCL2 Mmus\Bax Nc p53 Rbf rpr Scer\GAL4 skl stwl th W
Insertions (4)
	P{GSV1}stwl^GS3129 P{lacW}stwl^j6C3 P{Mae-UAS.6.11}brat^UY1131 P{Mae-UAS.6.11}stwl^UY823