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Citation
Schwartz, Y.B., Pirrotta, V. (2007). Polycomb silencing mechanisms and the management of genomic programmes.  Nat. Rev. Genet. 8(1): 9--22.
FlyBase ID
FBrf0193718
Publication Type
Review
Abstract
Polycomb group complexes, which are known to regulate homeotic genes, have now been found to control hundreds of other genes in mammals and insects. First believed to progressively assemble and package chromatin, they are now thought to be localized, but induce a methylation mark on histone H3 over a broad chromatin domain. Recent progress has changed our view of how these complexes are recruited, and how they affect chromatin and repress gene activity. Polycomb complexes function as global enforcers of epigenetically repressed states, balanced by an antagonistic state that is mediated by Trithorax. These epigenetic states must be reprogrammed when cells become committed to differentiation.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Genet.
    Title
    Nature Reviews. Genetics
    Publication Year
    2000-
    ISBN/ISSN
    1471-0056 1471-0064
    Data From Reference